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Προσδιορισμός του παράγοντα ενεργοποίησης των αιμοπεταλείων (PAF) στο αίμα ασθενών με διαβητική αμφιβληστροειδοπάθεια

Doctoral Dissertation uoadl:1327533 325 Read counter

Unit:
Τομέας Χειρουργικής
Library of the School of Health Sciences
Deposit date:
2017-02-06
Year:
2017
Author:
Pantazis Panagiotis
Dissertation committee:
Ιωάννης Λαδάς, Καθηγητής, Ιατρική, ΕΚΠΑ
Χρυσάνθη Κοθτσανδρέα, Καθηγήτρια, Ιατρική, ΕΚΠΑ
Κυριακοπούλου-Λυμπέρη Μαρία, Καθηγήτρια, Ιατρική, ΕΚΠΑ
Δημήτριος Μπρούζας, Αναπληρωτής Καθηγητής, Ιατρική, ΕΚΠΑ
Μαριλίτα Μόσχου, Αναπληρώτρια Καθηγήτρια, Ιατρική, ΕΚΠΑ
Μαρία Γαζούλη, Αναπληρώτρια Καθηγήτρια, Ιατρική, ΕΚΠΑ
Κωνσταντίνος Δρούτσας, Λέκτορας, Ιατρική, ΕΚΠΑ
Original Title:
Προσδιορισμός του παράγοντα ενεργοποίησης των αιμοπεταλείων (PAF) στο αίμα ασθενών με διαβητική αμφιβληστροειδοπάθεια
Languages:
Greek
Summary:
Background: Diabetic retinopathy (DR) is the most severe ocular complication of diabetes mellitus, accounting for 93 million of diabetic patients worldwide. Platelet activating factor (PAF) is a low molecular weight phospholipid, being implicating in enhanced vascular permeability and neovascularization observed in DR and other ocular diseases.
Objective: To assess the role of plasma PAF acetylhydrolase (PAF-AH) in pathogenesis and progression of DR.
Research design and methods: Sixty eight diabetics and 23 age-frequency-matched non-diabetic patients underwent blood sampling and the plasma PAF-AH activity was calculated. The diabetic patients were further classified into two groups, according to the Early Treatment Diabetic Retinopathy Study (ETDRS) classification, based on indirect fundoscopy and Fluorescein angiography. Thirty seven patients with non-proliferative DR (NPDR) and 31 patients with proliferative DR (PDR) were finally included in the study.
Results: The plasma PAF-AH activity was increased in diabetic patients compared to control group (control: 0.114µmol/min/ml, NPDR: 0.147µmol/min/ml and PDR: 0.206µmol/min/ml) and the differences in means were statistically significant among groups [One-Way ANOVA, p<0.0001, F= 10 (2,88)].
Conclusions: The activity of PAF-AH in the plasma increases in parallel with DR severity.
Main subject category:
Health Sciences
Keywords:
PAF, PAF-AH, Diabetic retinopathy
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
98
Number of pages:
94
File:
File access is restricted only to the intranet of UoA.
Persistent URL:
https://pergamos.lib.uoa.gr/uoa/dl/object/1327533

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