Unit:
Postgraduate Programme Biostatistics & Health Science DataLibrary of the School of Health Sciences
Supervisors info:
1. Δημοσθένης Παναγιωτάκος, Καθηγητής, Χαροκόπειο
2. Απόστολος Μπουρνέτας, Καθηγητής, Μαθηματικό, ΕΚΠΑ
3. Θεοδώρα Ψαλτοπούλου, Αναπληρώτρια Καθηγήτρια, Ιατρική, ΕΚΠΑ
Original Title:
Μετά-ανάλυση μελετών που ερευνούν τη σχέση της μεσογειακής διατροφής και των καρδιαγγειακών νοσημάτων
Translated title:
Meta-analysis of studies assesing the relationship between mediterranean diet and cardiovascular disease
Summary:
Introduction-Aim: In this meta-analysis the relationship between adherence to the Mediterranean diet and cardiovascular diseases was assessed.
Material-method: Meta-analysis of 19 studies that estimate the adherence to the Mediterranean diet using MedDietScore and its role in prevention of cardiovascular diseases as well as identification of the factors that affect this relationship using subgroup analysis. The studies under analysis were published between 2003 and 2015 and all of them are prospective. They were published in English and were selected from PUBMED electronic library. They were conducted in European countries and in the United States of America and evaluated adherence to Mediterranean diet as well as the endpoints of cardiovascular diseases-related morbidity and mortality in the same way. Check for publication bias using funnel-plots as well as sensitivity analysis were performed.
Results: This meta-analysis showed that for a diet score increase by 1 standard deviation the combined relative risk for cardiovascular disease was 0.907 with 95% confidence interval (0.894-0.919). After categorisation to studies of European and American origin, the relative risk was RR=0.921 (95% CI 0.907-0.934) and RR=0.814 (95% CI 0.783-0.847) respectively. When dividing our material to studies after and before 2010 the respective relative risks were RR=0.922 (95% CI 0.902-0.942) and RR=0.896 (95% CI 0.880-0.912).
Conclusion: This meta-analysis confirms the pre-existing knowledge that Mediterranean diet reduces the risk for cardiovascular diseases and this effect seems to be more significant in studies conducted outside Europe and in studies conducted before 2010.
Main subject category:
Health Sciences
Keywords:
Cardiovascular disease, Mediterranean diet.
