Unit:
Κατεύθυνση Μεταβολικά Νοσήματα των ΟστώνLibrary of the School of Health Sciences
Supervisors info:
Γεώργιος Λυρίτης, Ομότιμος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ιωάννης Τριανταφυλλόπουλος, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ισμήνη Δοντά Ισμήνη, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Ο ρόλος των αυτόλογων μεσεγχυματικών κυττάρων στην χονδρογένεση
Translated title:
The role of autologous mesenchymal cells in chondrogenesis
Summary:
It is known that cartilage does not have regenerative capability and a cartilage damage if not treated, may worsen and develop in cartilage degeneration and osteoarthritis. The biological-regenerative therapies aim to limit the cartilage degeneration and lead to new cartilage ,that could integrate into the existing one. Today, the primitive mesenchymal cells are used with spectacular results in orthopedic-sports medicine for treating osteoarthritis, cartilage lesions, as well as muscle, ligament and tendon injuries. The primate mesenchymal cells are mainly found in bone marrow, but also in οther tissues such as umbilical cord and fat. They are big cells able to create different types of cells, so there is interest in their use in regenerative medicine and in induction of chondrogenesis. Various protocols have been tested for transplantation of autologous mesenchymal cells into humans and experimental animals, using various growth factors and biomaterials as scaffolding, with encouraging clinical results.
Main subject category:
Medicine
Keywords:
Autologous mesenchymal cells, Cartilage damage, Chondrocytes, Chondrogenesis
Number of references:
145
