Unit:
Κατεύθυνση Σχεδιασμός και Ανάπτυξη νέων Φαρμακευτικών Ενώσεων - Φαρμακευτική ΧημείαLibrary of the School of Science
Author:
Papageorgiou Antria
Supervisors info:
Ανδρέας Τσοτίνης, Καθηγητής, Τμήμα Φαρμακευτικής, ΕΚΠΑ
Αντώνιος Κολοκούρης, Αναπληρωτής Καθηγητής, Τμήμα Φαρμακευτικής, ΕΚΠΑ
Ιωάννης Παπαναστασίου, Επίκουρος Καθηγητής, Τμήμα Φαρμακευτικής, ΕΚΠΑ
Original Title:
Σχεδιασμός, σύνθεση και μελέτη της αντιφυματικής δράσης νέων αδαμαντανικών παραγώγων του ισονιαζιδίου
Translated title:
Design, synthesis and antitubercular activity of new Isoniazid adamantane derivatives
Summary:
In the context of the present MSc dissertation, a series of new adamantane hydrazone derivatives of Isoniazid were designed, synthesized and studied with respect to their antitubercular potential. The new compounds were formed by coupling the corresponding 1-, 2- and 1,3-substituded or unsubstituted adamantane aldehydes with Isoniazid. Moreover, the isomeric hydrazones were prepared by coupling the corresponding 1-adamantanecarbohydrazides and 1,3-adamantanedicarbohydrazide with isonicotinic aldehyde. The NMR and molecular mechanics data obtained, led to the elucidation of the mixture of conformational conformers of the hydrazones. The pharmacological evaluation of the new adamantane hydrazones against Mycobacterium tuberculosis showed that the new adamantane hydrazones are equipotent to Isoniazid.
Main subject category:
Science
Other subject categories:
Pharmacy
Keywords:
antitubercular potential, isonicotinic aldehyde, hydrazones, adamantane hydrazones, Mycobacterium tuberculosis, isoniazid
Number of references:
179
