Κατεύθυνση Βιομηχανική Φαρμακευτική
Library of the School of Science

2017-07-06

2017

Gkinis Spyros

Δάλλας Παρασκευάς, Επίκουρος Καθηγητής, Φαρμακευτική, ΕΚΠΑ

IN VITRO μελέτες διαπερατότητας δικλοφενάκης και ριβαστιγμίνης διαμέσου της κεράτινης στιβάδας της επιδερμίδας και της μεμβράνης STRAT-M™

Greek

In vitro permeation studies of Diclofenac and Rivastigmine through skin and membrane STRAT-M™

In the present study, the usefulness of the synthetic membrane Strat-Μ™ as an alternative to human ski was evaluated by estimating the skin and membrane permeabilities of diclofenac and rivastigmine. An establishment of in vitro – in vivo correlation was also attempted. For this purpose the artificial membrane Strat-Μ™ and excised human skin were set in Franz- type diffusion cells and an amount of commercially available products for topical use of diclofenac and a transdermal therapeutic drug system of rivastigmine were applied to determine membrane permeation profiles. The results showed that the permeation results from Strat-Μ™ have a linear correlation with satisfying correlation coefficient R2 with the permeation results from human skin. However, permeation from Strat-Μ™ overestimated skin permeation in case of diclofenac while it underestimated skin permeation in case of rivastigmine. For the establishment of in vitro – in vivo correlation, data from bibliography were used. These data were elaborated with the method of deconvolution in order to obtain the absorption profiles after transdermal application. The in vitro – in vivo correlation showed that the in vitro results of excised skin and membrane Strat-Μ™ have a linear correlation with satisfying correlation coefficient R2 with the in vivo data. It seems that in vitro skin permeation techniques may be used in order to predict in vivo absorption of drugs.

Science

Pharmacy

transdermal drug delivery systems

Yes

5

Yes

170

168

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https://pergamos.lib.uoa.gr/uoa/dl/object/1708406