Unit:
Κατεύθυνση Εφαρμογές της Βιολογίας στην ΙατρικήLibrary of the School of Science
Author:
Delikoura Christina
Supervisors info:
Ισιδώρα Παπασιδέρη, Καθηγήτρια, Τομέας Βιολογίας Κυττάρου και Βιοφυσικής
Δημήτριος Μπέης, Ερευνητής Γ', Εργαστήριο Αναπτυξιακής Βιολογίας, Ίδρυμα Ιατροβιολογικών Ερευνών Ακαδημίας Αθηνών
Δημήτριος Στραβοπόδης, Επίκουρος Καθηγητής, Τομέας Βιολογίας Κυττάρου και Βιοφυσικής
Original Title:
Μελέτη μηχανισμών ανθρώπινων ασθενειών χρησιμοποιώντας το Zebrafish
Translated title:
Study of the mechanisms of human diseases using Zebrafish
Summary:
The capacity to regenerate organs or appendages after injury varies widely
between species. Although adult mammals have limited regenerative
potential, urodele amphibians and teleosts, like the zebrafish (Danio rerio),
can fully regenerate many internal organs and appendages. The zebrafish
caudal fin has emerged as a highly successful model for studying basic
mechanisms of tissue regeneration. There are many factors that play distinct
roles to that procedure as macrophages and neutrophils. These are key
mediators of inflammation that immerge during mammalian tissue repair. To
unravel the mechanisms of regeneration, the caudal fin of wild type and
transgenic adult and larvae zebrafish was amputated in order to study the
regeneration rate, the expression pattern of neutrophils and their possible
interaction.
Main subject category:
Science
Other subject categories:
Health Sciences
Keywords:
neutrophils, corticotropin-releasing hormone, telomerase, amputation, caudal fin, regeneration
Number of references:
206
