Unit:
ΠΜΣ Θρόμβωση-Αιμορραγία-Ιατρική των ΜεταγγίσεωνLibrary of the School of Health Sciences
Author:
Christaki Evangelia Eleni
Supervisors info:
Πολίτου Μαριάννα, Αναπληρώτρια Καθηγήτρια, Ιατρική σχολή, ΕΚΠΑ
Βασιλόπουλος Γεώργιος, Καθηγητής, Ιατρική σχολή, Πανεπιστήμιο Θεσσαλίας
Αθανασόπουλος Άγγελος, διευθυντής ΕΣΥ, Αιμοδοσία, ΕΑΝΠ Μεταξά
Original Title:
Παρασκευή ερυθρών αιμοσφαιρίων για μετάγγιση από αρχέγονα αιμοποιητικά κύτταρα
Translated title:
Ex vivo production of transfusable red blood cells using stem cells
Summary:
Blood transfusion may be considered as a form of heamatopoietic tissue transplantation and its first reports began in the 17th century after William Harvey’s studies of blood circulation system. The concept of transfusion immunology was introduced at the beginning of the 20th century with the discovery of ABO blood group antigens by Karl Landsteiner. The evolution of blood transfusion into a safe form of treatment that is applied daily in clinical practice, is based on a large range of scientific studies that have established strict control systems which are applied at all stages of transfusion. However, transfusion therapy continues to face several problems concerning all phases, from the collection of the blood to its administration. The sufficiency of donors, the transmission of pathogenic microorganisms, the alloimmunization and the overall costs of the process, turn the scientific interest to the search for alternative transfusion methods. The ex vivo production of red blood cells capable of replacing a unit of packed red blood cells is a very attractive prospect, let alone the idea of a massive production of such a product. Various scientific groups, exploiting the stem cell characteristics and the constantly renewed knowledge in the fields of collection, culture, preservation and expansion of these cells, have made significant progress towards the realization of such an idea. All three major sources of stem cells (HSPCs, hESCs and iPSCs) are thought to be capable of generating enormous amounts of red blood cells. By further studying and refining of in vitro red cell production protocols, it is anticipated that the economic and biotechnological obstacles of the current methods will be overcome even within the next ten years.
Main subject category:
Health Sciences
Keywords:
Blood transfusion, Ex vivo production, Stem cells
Number of references:
154
