Κατεύθυνση Χημική Ανάλυση-Έλεγχος Ποιότητας
Library of the School of Science

2018-03-12

2018

Gianak Olga

Δεληγιάννη Ελένη, Αναπληρώτρια Καθηγήτρια, Τμήμα Χημείας, Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης

Νανοδομές φιβροΐνης: Σύνθεση, ενθυλάκωση, απελευθέρωση φαρμάκων.

Greek

Nanostructures of fibroin, synthesis, encapsulation and drug release.

Silk fibroin (SF) is a protein–based bio macromolecule with excellent biocompatibility and biodegradability, for this reason silk fibroin micro-and nano-particles provide new options for drug delivery. In the present study, aqueous-based preparation methods for silk nanoparticles are presented, based on phase separation between silk fibroin and polyvinyl alcohol (SF/PVA). The encapsulation efficiency in SF/PVA nanoparticles was examined at a range of concentrations from 10 mg/L to 500 mg/L for the following drugs: pramipexole, curcumin and propranolol hydrochloride. The highest encapsulation entrapment for the SF/PVA nanoparticles loaded with curcumin was observed at 500 mg/L, for propranolol at 50 mg/L and for pramipexole at 35 mg/L. The drug release profiles of the above drug molecules were also examined and SF/PVA nanoparticles loaded with propranolol showed the highest release profile. Subsequently, in order to improve the encapsulation efficiency and drug release, a mix of silk fibroin and bovine serum albumin (SF-BSA/PVA) nanoparticles were prepared. Finally, magnetic silk fibroin nanoparticles were prepared targeting their ability to retain and to deliver the therapeutics at the preferred site. SF/PVA micro-and nanoparticles presented to have potential as drug delivery carriers in biomedical applications. The addition of BSA and magnetic nanoparticles improved the drug encapsulation and release.

Science

silk fibroin, drug delivery, magnetic silk fibroin, bovine serum albumin

No

0

Yes

45

103

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https://pergamos.lib.uoa.gr/uoa/dl/object/2694444