Antifungal screening of synthesized uridine analogues and modified natural metabolites of olives

Postgraduate Thesis uoadl:2777568 176 Read counter

Unit:
Κατεύθυνση Μικροβιακή Βιοτεχνολογία
Library of the School of Science
Deposit date:
2018-07-10
Year:
2018
Author:
Rafailidou Nafsika
Supervisors info:
Διαλλινάς Γεώργιος, Καθηγητής Μοριακής Μικροβιολογίας, Τομέας Βοτανικής, Τμήμα Βιολογίας Ε.Κ.Π.Α

Μικρός Εμμανουήλ, Καθηγητής του Τομέα Φαρμακευτικής Χημείας, Τμήμα Φαρμακευτικής Ε.Κ.Π.Α

Κωστάκης Ιωάννης, Επίκουρος Καθηγητής του Τομέα Φαρμακευτικής Χημείας, Τμήμα Φαρμακευτικής Ε.Κ.Π.Α
Original Title:
Έλεγχος της αντιμυκητιακής δράσης συνθετικών αναλόγων ουριδίνης και τροποποιημένων φυσικών μεταβολιτών της ελιάς
Languages:
Greek
Translated title:
Antifungal screening of synthesized uridine analogues and modified natural metabolites of olives
Summary:
Fungal infections constitute an emerging threat and a prevalent health problem. Currently used antifungals suffer from inefficiency, toxic side effects and developing drug-resistance. Additionally, over the last two decades no new classes of antifungals have been approved, emphasizing the urgent need for developing a novel generation of antifungals. In this Master’s Degree thesis, the antifungal activity of a series of chemically synthesized Hydroxytyrosol (HT) analogues as well as chemically synthesized uridine analogues, was tested. ΗΤ is one of the major phenolic compounds in olive oil, shown to possess antioxidant, antiproliferative and anti-inflammatory activitiy. As for uridine analogues, they have shown interesting antiprotozoan activity. There has been no other study on HT or uridine analogues as antifungals. It is shown that specific HT analogues have broad and strong antifungal activity, significantly stronger than the parent compound HT. The case is the same for uridine analogues, where antifungal action was observed for certain substances. Furthermore, using A. nidulans as an in vivo cellular model system, we show that those antifungal HT analogues have an unprecedented efficiency in fungal plasma membrane destruction. The results of this Master’s Degree thesis open the way for the development of a novel, efficient and safer class of antifungals.
Main subject category:
Science
Keywords:
Antifungal substances, ΗHydroxytyrosol analogues, Uridine analogues, Chemical analogues
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
84
Number of pages:
87

MSc Thesis Rafailidou Nausica.pdf
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