Κατεύθυνση Μικροβιακή Βιοτεχνολογία
Library of the School of Science

2018-07-10

2018

Rafailidou Nafsika

Διαλλινάς Γεώργιος, Καθηγητής Μοριακής Μικροβιολογίας, Τομέας Βοτανικής, Τμήμα Βιολογίας Ε.Κ.Π.Α

Μικρός Εμμανουήλ, Καθηγητής του Τομέα Φαρμακευτικής Χημείας, Τμήμα Φαρμακευτικής Ε.Κ.Π.Α

Κωστάκης Ιωάννης, Επίκουρος Καθηγητής του Τομέα Φαρμακευτικής Χημείας, Τμήμα Φαρμακευτικής Ε.Κ.Π.Α

Έλεγχος της αντιμυκητιακής δράσης συνθετικών αναλόγων ουριδίνης και τροποποιημένων φυσικών μεταβολιτών της ελιάς

Greek

Antifungal screening of synthesized uridine analogues and modified natural metabolites of olives

Fungal infections constitute an emerging threat and a prevalent health problem. Currently used antifungals suffer from inefficiency, toxic side effects and developing drug-resistance. Additionally, over the last two decades no new classes of antifungals have been approved, emphasizing the urgent need for developing a novel generation of antifungals. In this Master’s Degree thesis, the antifungal activity of a series of chemically synthesized Hydroxytyrosol (HT) analogues as well as chemically synthesized uridine analogues, was tested. ΗΤ is one of the major phenolic compounds in olive oil, shown to possess antioxidant, antiproliferative and anti-inflammatory activitiy. As for uridine analogues, they have shown interesting antiprotozoan activity. There has been no other study on HT or uridine analogues as antifungals. It is shown that specific HT analogues have broad and strong antifungal activity, significantly stronger than the parent compound HT. The case is the same for uridine analogues, where antifungal action was observed for certain substances. Furthermore, using A. nidulans as an in vivo cellular model system, we show that those antifungal HT analogues have an unprecedented efficiency in fungal plasma membrane destruction. The results of this Master’s Degree thesis open the way for the development of a novel, efficient and safer class of antifungals.

Science

Antifungal substances, ΗHydroxytyrosol analogues, Uridine analogues, Chemical analogues

No

0

Yes

84

87

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https://pergamos.lib.uoa.gr/uoa/dl/object/2777568