ΠΜΣ Μεταβολικά Νοσήματα των Οστών
Library of the School of Health Sciences

2018-10-31

2018

Pasanikolaki Athina

Γεώργιος Λυρίτης, Ομ. Καθηγητής, Ιατρική, ΕΚΠΑ
Ισμήνη-Νίκη Δοντά, Καθηγήτρια, Ιατρική, ΕΚΠΑ
Ιωάννης Τριανταφυλλόπουλος,Επ. Καθηγητής, Ιατρική, ΕΚΠΑ

Ο ρόλος της βιταμίνης D κατά την εξέλιξη των ειδών στην ομοιοστασία του ασβεστίου και του οστού

Greek

The role of vitamin D in calsium and bone homeostasis during evolution

Life derived from sea million years ago, with vitamin D being present as an inert product of a photochemical reaction between 7-dehydrocholestol and UVB. Through the evolution of life there are more polar metabolites of vitamin D. A full vitamin D endocrine system is characterized by the specific vitamin D transport protein (DBP), vitamin D metabolism enzymes belonging to the CYP P450 family, phosphorus regulating hormones such as FGF23, which has a great effect on metabolism or vitamin D activity, a VDR specific nuclear receptor and a complex intracellular signaling system for gene transcription. Mineralization is under the control of well-regulated SIBLING proteins and nearly all under the control of 1,25(OH)2D3. This endocrine system of vitamin D is found only in vertebrates and it is vital for the calcium and bone homeostasis, especially for terrestrial animals, which had to deal with a high-gravity and low-calcium environment. This study examines the role of vitamin D in the evolution of species and its mechanism of conversion from simple vitamin into a complex hormone endocrine system that regulates calcium and bone homeostasis.

Health Sciences

FGF23, VDR, Vitamin D, CYP, Sibling

No

0

Yes

116

66

File access is restricted only to the intranet of UoA.

https://pergamos.lib.uoa.gr/uoa/dl/object/2815546