Unit:
Κατεύθυνση Εφαρμογές της Βιολογίας στην ΙατρικήLibrary of the School of Science
Author:
Βασιλάτος-Λευτεράτος Spiridon
Supervisors info:
Δημήτριος Στραβοπόδης, Επίκουρος Καθηγητής του Τμήματος Βιολογίας, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών
Original Title:
Ο ρόλος της επίκτητης ανοσίας στην παθογένεια της νόσου Alzheimer's σε διαγονιδιακά ποντίκια
Translated title:
The role of the innate immunity in the pathogenesis of Alzheimer's disease in transgenic mice
Summary:
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive memory impairment and loss of cognitive skills. Pathologically, the disease is characterized by the formation of beta-amyloid plaques and neurofibrillary tangles. While the role of the innate immune system in the pathogenesis of the disease has been extensively studied, little is known about the role of the adaptive immune system in AD pathogenesis. The Ikaros protein is a transcription factor that is responsible for the maturation and differentiation of T- and B-lymphocytes and of NK cells. The deletion of this gene in transgenic mice (Ik-/-) results in a lack of the populations of these cells which leads to a lack of the adaptive immune system in general. To examine the role of the acquired immunity in AD, we tried to generate, via the right matings, 5xFAD Ik-/- transgenic mice. The 5xFAD line of mice are a good tool to study Alzheimer's disease because they rapidly accumulate beta-amyloid within their brains. Our analysis demonstrated significant reduction of the a-beta deposition in the hippocampus and cortex of the 5xFAD Ik+/- mice brains, when compared to the 5xFAD Ik+/+ mice.
Main subject category:
Science
Keywords:
Ikaros protein, Alzheimer's disease
