Unit:
ΠΜΣ Μεταβολικά Νοσήματα των ΟστώνLibrary of the School of Health Sciences
Author:
Katsouli Aikaterini
Supervisors info:
Λυρίτης Γεώργιος, Ομότιμος καθηγητής, Ιατρική, ΕΚΠΑ
Δοντά Ισμήνη-Νίκη, Καθηγήτρια, Ιατρική, ΕΚΠΑ
Τριανταφυλλόπουλος Ιωάννης, Επίκουρος Καθηγητής, Ιατρική, ΕΚΠΑ
Original Title:
Πειραματικές προσεγγίσεις στη μεταβολή της εγκεφαλικής λειτουργίας ως προς τα επίπεδα των μονοαμινών κατά το μυοσκελετικό τραυματισμό
Translated title:
Experimental approaches to the central nervous system physiology with respect to the monoamine levels after musculoskeletal injury
Summary:
Background: Musculoskeletal trauma is a leading cause of morbidity worldwide and a major black hole in socioeconimics. The medical-biological knowhow of trauma counteracting mechanisms remains to an extend unraveled, gathering significantly the scientific community’s light of interest. Aim: The study of monoamines levels ( serotonin, dopamine, noradrenalin and adrenaline) and cortisol in peripheral vein blood sample during the acute phase of musculoskeletal injury. Materials, Patients and Methods: 62 trauma patients aged 16 to 80 were gathered after crash accident or fall from height, 11 women and 51 men. On arrival at the emergency room clinical examination was performed, injuries were addressed and blood samples were obtained for laboratory examination and neurochemical study. Classification to case 30 patients and control 32 patient was then performed. Results: We observed elevation in all monoamines and cortisol levels in respect of the basic reference values of basic population. The case group demonstrated significant elevation in cortisol versus the control group 14.8 ± 8.37 vs. 25.67 ± 9.54 ug/dl (p= 0.000028) but not in monoamines levels. However serotonin, dopamine and catecholamines produced interesting results regarding the specific characteristics of trauma (gender, cause, way, form and site of injury), with statistically significant p values<0.05. Conclusions: The study supports that there is an alteration and mostly elevation in neurochemical molecules that are implicated in trauma response mechanisms. However the results suggest that there is room for further examination and study to this direction and a possible connection to conditions observed further down in the body response in trauma such as late onset complication.
Main subject category:
Health Sciences
Keywords:
Monoamines, Cortisol, Serotonin, Dopamine, Adrenalin, Noradrenalin, Catecholamines, Trauma, Injury
