Pergamos - Library and Information Center of National and Kapodistrian University of Athens

Unit:

Κατεύθυνση Παιδιατρική Λοιμωξιολογία
Library of the School of Health Sciences

Deposit date:

2019-03-19

Year:

2019

Author:

Maltezou Panagiota Georgia

Supervisors info:

Παπαευαγγέλου Βασιλική, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Σιαχανίδου Σουλτάνα, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Σπυρίδης Νικόλαος, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ

Original Title:

Μελέτη της μακροπρόθεσμης έκβασης νεογνών με συγγενή λοίμωξη από κυτταρομεγαλοϊό (CMV) μετά από πρωτοπαθή ή δευτεροπαθή CMV λοίμωξη της μητέρας: Συστηματική ανασκόπηση και μεταανάλυση

Languages:

Greek

Translated title:

Long-term sequelae in infants congenitally cytomegalovirus infected born to mothers with primary versus non-primary cytomegalovirus infection: a systematic review and metaanalysis

Summary:

BACKGROUND: Cytomegalovirus (CMV) is the most common congenitally transmitted infection worldwide. The decision on whether screening mothers or newborns is best, is significantly depended on whether the type of maternal CMV infection during pregnancy is associated with the outcome in congenitally CMV infected children.
METHODS: We systematically reviewed articles from the Medline and Scopus Database, which were published from January 1980 till December 2018 and compared neonatal symptoms and long-term sequelae of congenitally CMV (cCMV) infected infants born to mothers with primary and non-primary CMV infection.
RESULTS: Nine articles met our inclusion criteria. The meta-analysis and the meta-regression models performed indicate that the chances of symptomatic neonatal CMV disease do not differ statistically significantly among infants born to mothers with primary and non-primary CMV infection during pregnancy [OR=1.33 (95% CI; 0.84-2.11), p=0.226]. In addition to this, the outcomes of SNHL [OR=0.89 (95% CI; 0.61-1.29), p=0.535], bilateral SNHL [OR=1.04 (95% CI; 0.53-2.07), p=0.903] were similar between the two groups of children during the follow-up. The OR for other neurologic sequelae was 0.85 (95% CI; 0.52-1.39, p=0.518) and not statistically significant.
CONCLUSIONS: The importance of non-primary CMV infection among pregnant women is stressed. Moreover, it seems to contribute substantially to the burden of congenital CMV morbidity.

Main subject category:

Health Sciences

Keywords:

Cytomegalovirus, Congenital infection, Primary, Non-primary, Sequelae, Sensorineural hearing loss

Index:

Number of index pages:

Contains images:

Yes

Number of references:

119

Number of pages:

File: