Unit:
Κατεύθυνση Διεθνής Ιατρική - Διαχείριση Κρίσεων ΥγείαςLibrary of the School of Health Sciences
Supervisors info:
Κοντός Μιχαήλ, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Γεωργόπουλος Σωτήριος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Καραβοκυρός Ιωάννης, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Η επίπτωση και ο επιπολασμός της νεφρικής νόσου σε HIV- οροθετικούς ασθενείς: Μια αναδρομική μελέτη παρατήρησης από το Εθνικό Κέντρο Αναφοράς HIV/AIDS Βορείου Ελλάδας
Translated title:
Renal disease among HIV seropositive patients in Northern Greece: An assessment of the prevalence, clinical features and risk factors
Summary:
Background: Renal disease is one of the leading causes of morbidity and mortality among people infected with human immunodeficiency virus (HIV). Patients with HIV are at high risk for both Acute Kidney Injury (AKI) and Chronic Kidney Disease (CKD). The prevalence and incidence of both AKI and CKD have decreased with the widespread use of ART, but remain higher than in the general population. The aim of our retrospective, cross- sectional study was to identify the epidemiological traits of renal disease among HIV seropositive patients in our geographic area and describe possible risk factors.
Materials and Methods: We enrolled 326 HIV-positive patients from the Reference Center of HIV and Infectious Diseases of Northern Greece. Data were collected between January and June 2018.
Results: The incidence of both AKI and CKD were 4.9% and 2.1% respectively. Older age, hypertension, diabetes mellitus, and the use of tenofovir or ritonavir were independently associated with renal dysfunction in HIV positive patients.
Conclusions: Kidney biopsies are an essential tool in order to have more clear results as far as the etiology and pathogenesis of renal disease in HIV patients are concerned. Careful clinical and laboratory monitoring of renal function is needed in HIV-positive individuals.
Main subject category:
Health Sciences
Keywords:
Human Immunodeficiency Virus(HIV), Renal disease, Antiretroviral therapy
