Κατεύθυνση Καρδιοαναπνευστική Αναζωογόνηση
Library of the School of Health Sciences

2019-04-11

2019

Kyriazopoulou Evdoxia

Ευαγγελία Κουσκούνη, Ομότιμη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Θεόδωρος Ξάνθος, Καθηγητής, Ιατρική Σχολή, Ευρωπαϊκό Πανεπιστήμιο Κύπρου
Αθανάσιος Χαλκιάς, Επίκουρος Καθηγητής, Τμήμα Ιατρικής, Πανεπιστήμιο Θεσσαλίας

Η βραδυκαρδία κατά τη στοχευμένη διαχείριση θερμοκρασίας: Συσχέτιση με την έκβαση

Greek

Sinus-bradycardia during targeted temperature management: A systematic review and meta-analysis

Introduction The beneficial effect of sinus-bradycardia during targeted temperature management (TTM) in cardiac arrest patients remains doubtful. We aimed to investigate the impact of sinus-bradycardia on survival and neurological outcome.
Methods MEDLINE(PubMed), Cochrane, Google Scholar and http://www.clinicaltrials.gov databases were searched for studies reporting on comatose post-cardiac arrest patients presenting sinus-bradycardia during TTM. Outcomes were the 180-day survival and final neurologic function assessed by the Cerebral Performance Category (CPC) scale. The effect size on study outcomes is presented as odds ratio (OR) with 95% confidence interval (CI).
Results Two studies with 1184 patients were included. Compared to no-sinus-bradycardia group, in patients with sinus bradycardia below 50 bpm a significant effect of sinus-bradycardia on reduction of 180-day mortality was reported (OR 0.42; 95% CI: 0.29-0.59). No heterogeneity was detected.
Conclusions Sinus-bradycardia below 50 bpm during TTM may be protective and should be considered in comatose post-cardiac arrest patients.

Health Sciences

Targeted temperature management, Bradycardia, Mortality, Neurological outcome

No

0

Yes

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https://pergamos.lib.uoa.gr/uoa/dl/object/2867606