Unit:
Κατεύθυνση Μεταβολικά Νοσήματα των ΟστώνLibrary of the School of Health Sciences
Author:
Christoforidis Christos
Supervisors info:
Γεώργιος Π. Λυρίτης, Ομότιμος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ισμήνη-Νίκη Δοντά, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Ιωάννης Τριανταφυλλόπουλος, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Ο Ρόλος των Ελεύθερων Ριζών του Οξυγόνου στην παθογένεια της ιδιοπαθούς Οστεοαρθρίτιδας
Translated title:
The Role of Free Radicals in Primary Knee Osteoarthritis Pathogenesis
Summary:
Although overproduction of free oxygen radicals can be harmful to cell biology, there is much evidence that moderate levels of free oxygen radicals control cell signaling and gene expression, while retaining redox signaling. In the articular cartilage, low concentrations of free radicals of oxygen normally participate in intracellular signaling and normal homeostasis of articular cartilage, synovium and subchondral bone. When, for specific reasons such as aging, mechanical factors and cytokine activity, free oxygen radicals are overproduced, the resulting oxidative stress is involved in the pathogenesis of idiopathic osteoarthritis through the induction of inflammatory processes, increased chondrocyte apoptosis, degradation of extracellular matrix, mitochondrial dysfunction of chondrocytes, synovial inflammation and dysfunction of subchondral bone
Main subject category:
Health Sciences
Keywords:
Osteoarthritis, Free radicals, Oxygen, Oxidative stress, Chondrocytes
Number of references:
156
