Τομέας Κοινωνικής Ιατρικής - Ψυχιατρικής και Νευρολογίας
Library of the School of Health Sciences

2019-09-06

2019

Daskalopoulou Eugenia

Γεώργιος Χριστοδούλου, Ομότιμος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Χαράλαμπος Παπαγεωργίου, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ, Επιβλέπων
Δημήτριος Δικαίος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Θωμάς Παπαρρηγόπουλος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Εμμανουήλ Ρίζος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Βασίλειος Μασδράκης, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Μαρίνα Οικονόμου, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ

Νευροενδοκρινική μελέτη σεροτονινεργικών και ντοπαμινεργικών παραμέτρων στη Σχιζοφρένεια: Συσχετίσεις με θετικά και αρνητικά συμπτώματα

Greek

Neuroendocrine study of serotoninergic and dopaminergic parameters in schizophrenia. Correlations with positive and negative symptoms

Schizophrenia is a chronic disease which begins in adolescence or early adulthood and causes lifelong impairment. There is evidence that the duration of untreated psychosis may affect both the course and outcome of treatment in patients with schizophrenia. In the present study, neuroendocrine probes were used to test the hypothesis that untreated psychosis may induce time-dependent changes in central serotonergic and dopaminergic neurotransmission. Prolactin responses to the administration of clomipramine (i.v.) and haloperidol (i.m.) were measured in drug-naïve patients with DSM-IV diagnoses of schizophreniform or schizophrenic disorders and in healthy control subjects. The results provide evidence that the persistence of psychotic psychopathology induces secondary neuroadaptive effects, which seem to involve changes in central serotonergic function. The relationship between plasma basic levels of testosterone, cortisol, and prolactin and the severity of psychopathology in these patients with schizophreniform or schizophrenic disorder, was also evaluated. Plasma levels of testosterone were negatively correlated with the severity of negative symptoms. There was also a positive correlation between prolactin plasma levels and positive symptoms score and between cortisol levels and the cognitive symptoms score. The present study indicates that assessment of sex hormones and function of the hypothalamic–pituitary– adrenal and/or hypothalamic– pituitary–gonadotropin axis could be an important biological marker for the severity of sub clusters of positive, negative and cognitive symptoms in schizophrenia.

Health Sciences

Schizophrenia, Serotonin, Dopamine, Drug-naive, Hormones, Psychopathology

No

0

Yes

321

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https://pergamos.lib.uoa.gr/uoa/dl/object/2880514