Unit:
Κατεύθυνση ΝευροεπιστήμεςLibrary of the School of Science
Author:
Papadopoulou Anastasia-Konstantina
Supervisors info:
Ευθυμία Κιτράκη, Καθηγήτρια, Οδοντιατρική Σχολή, ΕΚΠΑ
Αντώνιος Σταματάκης, Αναπληρωτής καθηγητής, Τμήμα Νοσηλευτικής, ΕΚΠΑ
Original Title:
Effects of prenatal exposure to endocrine disruptors in mice behavior and brain neurochemistry
Translated title:
Effects of prenatal exposure to endocrine disruptors in mice behavior and brain neurochemistry
Summary:
Endocrine disrupting compounds (EDCs) are substances that can disturb the normal function of endogenous hormones in any manner. Recently, SELMA study of a pregnant women cohort showed that many of the known EDCs are present in the urine and the sera of these women and can potentially harm their offspring in multiple levels, including in their neuronal development. In the frame of EDC-MixRisk, the mixtures of EDCs associated with neurodevelopmental impairment in children of the SELMA study were defined. In the present study, we exposed pregnant mice dams to different doses of a mixture of endocrine disruptors during gestation. Then, in their adult male offspring we investigated the effects of this mixture on certain aspects of behavior and expression pattern of genes related to stress responses. We showed that exposure to high –relevant to human exposure-doses of this mixture of compounds induces hyperactivity and increases active coping in adult male mice, through deregulation of the Hypothalamus-Pituitary-Adrenals axis. These results indicate an association with equivalent phenotypes in patients with neurodevelopmental disorders and are influential for further investigation and prevention of the effects of EDCs.
Main subject category:
Science
Keywords:
endocrine disruptors, neurodevelopment, hyperactivity
