Unit:
Κατεύθυνση Οργανική Σύνθεση και Εφαρμογές της στη Χημική ΒιομηχανίαLibrary of the School of Science
Supervisors info:
Χριστόφορος Κόκοτος, Επίκουρος Καθηγητής, Τμήμα Χημείας, Ε.Κ.Π.Α
Θωμάς Μαυρομούστακος, Καθηγητής, Τμήμα Χημείας, Ε.Κ.Π.Α
Γεώργιος Βουγιουκαλάκης, Επίκουρος Καθηγητής, Τμήμα Χημείας, Ε.Κ.Π.Α
Original Title:
Σύνθεση Οργανικών Ενώσεων που Φέρουν Φθόριο και Εφαρμογή τους σε Ασύμμετρους Οργανοκαταλυτικούς Μετασχηματισμούς
Translated title:
Synthesis of Organic Compounds containing Fluorine Moieties and utilization in Asymmetric Organocatalytic Reactions
Summary:
Organocatalysis is a new and rapidly developing field of catalysis. In the last few years, the scientific community has turned its focus on the development of milder and more eco-friendly methods, including the use of organocatalysts that do not require organic solvents, as well as the decrease of metal catalysts as a mean to emphasize the turn to Green Chemistry. The Laboratory of Organic Chemistry of the University of Athens has already developed catalysts and methods for many organic transformations, for example the asymmetric α-chlorination of aldehydes that can lead to many valuable building blocks via a Linchpin manifold.
In the present thesis, in the first chapter the concept of Organocatalysis is being introduced, as well as some key contributions in the field and In the second chapter, the organocatalytic asymmetric aldol reaction is being reviewed, focusing on the scaffold of the organocatalyst. In the third chapter a review on different methodologies on the oxidation of olefins to epoxides, whereas the fourth chapter is a review about the α-chlorination of aldehydes, different synthetic pathways for Levetiracetam and different takes on the olefination of thiophenes.
The following fifth chapter presents a brief overview of the aims the experimental part of this thesis. The next chapters refer to the experiments that were done. In the sixth chapter the use of a new organocatalyst for the asymmetric Aldol reaction in aqueous or aquatic media is described. The seventh chapter is next and analyzes the synthesis of activated ketones that are based in different amino acids for the asymmetric epoxidation of olefins. The research for an organocatalytic enantioselective synthesis for Levetiracetam using the asymmetric α-chlorination of aldehydes, is the main subject of chapter eight. Finally, in the nineth chapter the experimental procedures are described as well as the spectroscopic data of the synthesized compound.
Main subject category:
Science
Keywords:
Organocatalytic, asymmetric, aldol, epoxidation, Levetiracetam
Number of references:
192
