Supervisors info:
Μαστοράκος Γεώργιος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ, Επιβλέπων
Βαλσαμακης Γεώργιος, MD, PhD
Παπαευαγγελου Βασιλική, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Summary:
Diabetes mellitus is a chronic metabolic disease with serious health complications for patients. There is a special category in diabetes which appears for the first-time during pregnancy, called gestational diabetes mellitus. LRP5 is a transmembrane protein and a co-receptor in canonical Wnt pathway.
The aim of this study is to compare the expression of LRP5 in placental tissue of women with gestational diabetes mellitus (GDM). The experimental part involves protein isolation of the placentas of both healthy women and with GDM and Western– Blot analysis. Somatometric characteristics are also included in this study, from both women and their infants. There was no significant difference found in these characteristics between healthy and women with GDM. Infant body measurements also presented no significant difference between groups but umbilical glucose was found higher in the GDM group compared with healthy group. LRP5 protein was found significantly higher in women with GDM in comparison with healthy group. There are no other studies found about LRP5 expression in gestational diabetes mellitus
