Κατεύθυνση Παιδιατρική Λοιμωξιολογία
Library of the School of Health Sciences

2019-12-02

2019

Koufoglou Eleni

Μίχος Αθανάσιος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ, Επιβλέπων
Παπαευαγγέλου Βασιλική, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Σιαχανίδου Σουλτάνα, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ

Επίδραση της προφυλακτικής χορήγησης αντιπυρετικών στην ανοσιακή απάντηση μετά από εμβολιασμό: Συστηματική Ανασκόπηση

Greek

Effect of prophylactic administration of antipyretics on immune response of routine vaccination: Systematic Review

Background: Prophylactic antipyretic administration at the time of immunization seems to decrease the adverse effect of vaccination. The aim of this systematic review is to assess the existing literature concerning the effect of prophylactic use of antipyretics on immune response following vaccination.
Methods: A systematic review of literature concerning the immune response to vaccines after antipyretic administration was performed. A broad search of literature up until June 2019 was conducted in electronic databases of Pubmed and Scopus, as well as in clinical trials database. Randomized controlled trials as well as observational studies, published in English language, were included in the study with no age limitation.
Results: Published studies that met the eligibility criteria concerned the following vaccines: Pneumococcus (n=5), Diphtheria-Tetanus-Pertussis-Polio-Haemophilus influenzae type b (DTaP-IPV-Hib) (n=5), Hepatitis B (n=5), Rotavirus (n=1), Meningococcus type B (4CMenB) (n=1) and Ιnfluenzae virus (n=4). The prophylactic administration of paracetamol caused a significant decrease in the immune response to certain pneumococcal serotypes in 5/5 studies, pertussis toxin in 1/5 studies and tetanus (1/5). The use of ibuprofen had a negative effect on pertussis (FHA, PT) in 1/2 studies and Hepatitis Β (1/2). Despite the reduction, the antibody titers remained above protective levels.
Conclusion: Although the reviewed studies had significant heterogeneity in design, antipyretic administration seems to have an important effect on immune response. More well-designed studies need to be conducted in order to provide clear evidence concerning the association of immunogenicity with the type of antipyretics and the time of administration.

Health Sciences

Vaccination, Antipyretics, Paracetamol, Ibuprofen, Immunogenicity, Immune response

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Yes

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https://pergamos.lib.uoa.gr/uoa/dl/object/2886703