Unit:
Τομέας ΧειρουργικήςLibrary of the School of Health Sciences
Author:
Chaniotakis Ioannis
Dissertation committee:
1. Χρήστος Κ. Σαλάκος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
2. Χρούσος Γεώργιος, Ομότιμος Καθηγητής Παιδιατρικής και Ενδοκρινολογίας, Επικεφαλής Έδρας UNESCO Εφηβικής Υγείας και Ιατρικής, ΕΚΠΑ
3. Νικόλαος Νικητέας, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
4. Κόντζογλου Κωνσταντίνος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
5. Ευστάθιος Α. Αντωνίου, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
6. Νικολέττα Μ. Ιακωβίδου, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
7. Σαλάκος Νικόλαος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Συγκριτική μελέτη της νευροενδοκρινικής και φλεγμονώδους απόκρισης του οργανισμού στην κοιλιακή και λαπαροσκοπική ολική ωοθηκυστερεκτομή. Πειραματική μελέτη σε κονίκλους.
Translated title:
Evaluation of neuroendocrine and inflammation response between the conventional and laparoscopic total ovariohysterectomy. Experimental study in rabbits.
Summary:
The aim of this study was to evaluate the neuroendocrine and inflammation response to laparoscopic total ovariohysterectomy in rabbits, by comparing surgical stress markers of laparoscopic group with those of conventional open ovariohysterectomy and open ovariohysterectomy with pre-incisional local anaesthesia groups. Blood was sampled from 18 rabbits, of which 6 underwent laparoscopic total ovariohysterectomy (TOH), 6 conventional open TOH and 6 conventional open TOH with pre-incisional local anaesthesia, 30 minutes before induction of anesthesia (T0), immediately after skin incision (T1), 90 minutes postoperatively (T2), and 24 hours postoperatively (T3). Cortisol and CRP serum, and ACTH, TNF-a, adrenaline, noradrenaline and IL-6 plasma concentrations were evaluated. Laparoscopic TOH in rabbits has advantages over the open surgical technique because it causes less surgical stress response in terms of serum cortisol concentrations immediately after skin incision (p=0.04) as well as plasma adrenaline (p=0.035) and TNF-a (p=0.047) concentrations 24 h postoperatively.
Main subject category:
Health Sciences
Keywords:
Lararoscopy, Local Anaesthesia, Surgical stress response, rabbit, total ovariohysterectomy
Number of references:
118
