Unit:
Library of the School of Health SciencesΤομέας Κοινωνικής Ιατρικής - Ψυχιατρικής και Νευρολογίας
Author:
Kormas Konstantinos
Dissertation committee:
Λεωνίδας Στεφανής, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ελισάβετ Καπάκη, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Παναγιώτης Σίμος, Καθηγητής Εξελικτικής Νευροψυχολογίας, Τμήμα Ιατρικής Σχολής, Πανεπιστήμιο Κρήτης
Κωνσταντίνος Πόταγας, Αναπληρωτής Καθηγητής Νευρολογίας-Νευροψυχολογίας, Τμήμα Ιατρικής Σχολής, ΕΚΠΑ
Ιωάννης Ζαλώνης, Αναπληρωτής Καθηγητής Ψυχολογίας - Νευροψυχολογίας, Τμήμα Ιατρικής Σχολής, ΕΚΠΑ
Σωκράτης Παπαγεωργίου, Αναπληρωτής Καθηγητής Νευρολογίας – Νευροψυχολογίας, Τμήμα Ιατρικής Σχολής, ΕΚΠΑ
Γεώργιος Παρασκευάς, Αναπληρωτής Καθηγητής Νευρολογίας, Τμήμα Ιατρικής Σχολής, ΕΚΠΑ
Original Title:
Νευροψυχολογική διερεύνηση της μνήμης ονομάτων - προσώπων σε φυσιολογικό πληθυσμό και ασθενείς με νευροεκφυλιστικά νοσήματα
Translated title:
Neuropsychological investigation of faces - names memory in normal population and patients with neurodegenerative diseases
Summary:
The present doctoral thesis examined the associative memory of faces-names in normal aging population and patients with neurodegenerative diseases.
The construct, convergent and divergent validity and test-retest reliability of GR-FNAME12 in a sample of 216 cognitively normal elderly individuals were confirmed. It was found that the Greek version of the FNAME12 had adequate psychometric properties and could be administered to Greek-speaking individuals for clinical and research purposes. Furthermore, the aim of the present doctoral thesis was to compare the performance on GR-FNAME12 between normal individuals, individuals with subjective memory complaints and individuals with a diagnosis of aMCI. GR-FNAME12 was found to differentiate performance between the subgroups of preclinical AD period and the normal individuals. It appeared to have adequate diagnostic accuracy with satisfactory sensitivity and specificity values making it a reliable clinical tool. Moreover, we examined the performance of patients with Parkinson’s disease (PD) with different cognitive profiles on GR-FNAME12. The results revealed that the group with executive and additional visuospatial deficits demonstrated significantly lower scores on FNAME. This finding indicates the possible clinical utility of FNAME for screening patients with PD with distinct cognitive profiles. Finally, our results support that the delayed free recall appears to be more severely affected in the cross visual-verbal and visual memory modalities than in verbal-memory modalities in the early phase of PD progression. In summary, the findings of this doctoral thesis enrich the existing literature and could have important application in public health for the prevention and diagnosis of memory deficits in the early stage of neurodegenerative diseases on the Greek population.
Main subject category:
Health Sciences
Keywords:
Associative memory, Face-name memory, Standardization of neuropsychological test, Normative data, Subjective memory complaints, Mild Cognitive Impairment, Alzheimer's disease, Parkinson's disease
Number of references:
169
