Unit:
Κατεύθυνση ΝευροεπιστήμεςLibrary of the School of Science
Supervisors info:
Σκαλιώρα Ειρήνη, Καθηγήτρια Γνωσιακής Επιστήμης, Τμήμα Φιλοσοφίας και Ιστορίας της Επιστήμης, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών και Συνεργαζόμενη Ερευνήτρια, Εργαστήριο Νευροφυσιολογίας, Κέντρο Βασικής Έρευνας, Ίδρυμα Ιατροβιολογικών Ερευνών Ακαδημίας Αθηνών
Original Title:
Who gives in first? Region-specific vulnerability to epileptogenesis and the role of the endogenous cortical network activity
Translated title:
Who gives in first? Region-specific vulnerability to epileptogenesis and the role of the endogenous cortical network activity
Summary:
Distinct brain regions display different seizure thresholds, as evident by epidemiological studies, but previous in vitro studies that have attempted to investigate seizure thresholds in different brain regions have yielded conflicting results. Furthermore, studying the connection between slow wave sleep and epilepsy investigation might help elucidate underlying mechanisms of epileptogenesis. Here we used an in vitro model of epileptiform activity to examine the seizure threshold of two different neocortical regions (M1, S1BF) and a hippocampal region (CA3). We found that the neocortex exhibits a reduced epileptiform activity threshold compared to the hippocampus, which is strongly associated with the presence of Up state activity. We also examined how the properties of the physiological endogenous cortical network activity change as it transitions to a hypersynchronous paroxysmal state. Our data reveal that under epileptogenic conditions, Up state activity is accelerated, until Up states are eliminated and replaced by epileptiform discharges.
Main subject category:
Science
Keywords:
CA3, epileptiform, hippocampus, low Mg2+, M1, neocortex, S1BF, Up state
