Τομέας Χειρουργικής
Library of the School of Health Sciences

2020-02-10

2020

Fiamegkos Alexandros

Χαράλαμπος Δεληβελιώτης, Καθηγητής, Ιατρική, ΕΚΠΑ
Μιχαήλ Χρυσοφός, Καθηγητής, Ιατρική, ΕΚΠΑ
Ανδρέας Σκολαρίκος, Καθηγητής, Ιατρική, ΕΚΠΑ
Χρήστος Αλαμανής, Καθηγητής, Ιατρική, ΕΚΠΑ
Ιωάννης Βαρκαράκης, Αναπλ. Καθηγητής, Ιατρική, ΕΚΠΑ
Αθανάσιος Παπατσώρης, Αναπλ. Καθηγητής, Ιατρική, ΕΚΠΑ
Ηρακλής Μητσογιάννης, Αναπλ. Καθηγητής, Ιατρική, ΕΚΠΑ

Ο ρόλος της ολικής και της ελεύθερης τεστοστερόνης ως προγνωστικός δείκτης θετικοποίησης της επαναληπτικής βιοψίας σε ασθενείς με PSA > 4 ng/ml και προηγούμενη αρνητική βιοψία για καρκίνο προστάτου ή με διάγνωση ΡΙΝ.

Greek

Serum testosterone as a biomarker for second prostatic biopsy in men with negative first biopsy for prostatic cancer and PSA>4ng/ml, or with PIN biopsy result.

INTRODUCTION: Data from animal, clinical and prevention studies support the role of androgens in prostate cancer growth, proliferation and progression. Results of serum based epidemiologic studies in humans, however, have been inconclusive. The present study aims to define whether serum testosterone can be used as a predictor of a positive second biopsy in males considered for re-biopsy.
MATERIAL AND METHODS: The study included 320 men who underwent a prostatic biopsy in our department from October 2011 until June 2012. Total testosterone, free testosterone, bioavailable testosterone and prostate pathology were evaluated in all cases. Patients undergoing a second biopsy were identified and biopsy results were statistically analyzed.
RESULTS: Forty men (12.5%) were assessed with a second biopsy. The diagnosis of the second biopsy was High Grade Intraepithelial Neoplasia in 14 patients (35%) and Prostate Cancer in 12 patients (30%). The comparison of prostatic volume, total testosterone, sex hormone binding globulin, free testosterone, bioavailable testosterone and albumin showed that patients with cancer of the prostate had significantly greater levels of total testosterone (p=0.036) and bioavailable T (p=0.005).
CONCLUSION: In our study, higher total testosterone and bioavailable testosterone levels were associated with a cancer diagnosis at re-biopsy. Our results indicate a possible role for total and bioavailable testosterone in predicting the presence of prostate cancer in patients considered for re-biopsy.

Health Sciences

Prostate, Cancer, Biopsy, Testosterone, Androgens

No

0

Yes

261

143

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https://pergamos.lib.uoa.gr/uoa/dl/object/2897014