Unit:
Faculty of MedicineLibrary of the School of Health Sciences
Author:
Korovessi Paraskevi
Dissertation committee:
Μαρία Τσολιά, Καθηγήτρια , Ιατρική Σχολή, ΕΚΠΑ
Αθανάσιος Μίχος , Αναπληρωτής Καθηγητής ,Ιατρική Σχολή, ΕΚΠΑ
Αναστασία Γαρούφη,Αναπληρώτρια Καθηγήτρια,Ιατρική Σχολή, ΕΚΠΑ
Παρασκευή Ξεπαπαδάκη, Επίκουρη Καθηγήτρια,Ιατρική Σχολή, ΕΚΠΑ
Νικόλαος Σπυρίδης, Επίκουρος Καθηγητής,Ιατρική Σχολή, ΕΚΠΑ
Γεώργιος Βάρτζελης, Επίκουρος Καθηγητής,Ιατρική Σχολή, ΕΚΠΑ
Λυδία Κόσσυβα, Επίκουρη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Φλεγμονή στη ρινίτιδα και το άσθμα. Συσχέτιση και κινητική
Translated title:
Association and kinetics of airway inflammation in rhinitis and asthma
Summary:
Fractional exhaled nitric oxide (FeNO) is a non-invasive marker for eosinophilic airway inflammation and has been used for monitoring asthma. Here we assess the characteristics of FeNO from preschool to school age, in parallel to asthma and rhinitis activity.167 asthmatic children and 66 healthy age-matched were included in the 2-year prospective PreDicta study evaluating wheeze/asthma persistence in preschool-aged children.
Information on asthma/rhinitis activity, infections and atopy were recorded at baseline. Follow up visits were performed at 6 months intervals in the asthmatic group, and on exacerbation/cold and 4-6 weeks later.
We obtained 539 FeNO measurements in asthmatics and 42 in controls. At baseline, FeNO did not differ between groups (medians respectively, 3.0 vs 2.0 ppb). FeNO values at 6, 12, 18 and 24 months (respectively, 4.0 CI: 0.0-8.6, 6.0 CI: 2.8-12.0, 8.0 CI:4.0-14.0, 8.5 CI:4.4-14.5 ppb) increased with age (correlation p=<0.001) and atopy (p=0.03). FeNO non-significantly increased from baseline to symptomatic visit, while decreased at convalescence (p=0.007). Markers of disease activity, such as wheeze episodes and days with asthma were associated with increased FeNO values during the study (all p<0.05).
Age, atopy and disease activity are important FeNO determinants in preschool children. Longitudinal and individualized FeNO assessment may be valuable in monitoring asthmatic children with recurrent wheezing or mild asthma.
Main subject category:
Health Sciences
Keywords:
Asthma, Inflammation, Evolution
Number of references:
208
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Korovessi Paraskevi PhD.pdf
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