Unit:
Faculty of MedicineLibrary of the School of Health Sciences
Dissertation committee:
Ιωάννης Ξενέλης, Ομότιμος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ, Επιβλέπων
Σταύρος Κορρές, Ομότιμος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ανδριάνα Καλιώρα, Επίκουρη Καθηγήτρια, Τμήμα Επιστήμης Διαιτολογίας-Διατροφής, Χαροκόπειο Πανεπιστήμιο
Mαρία Γαζούλη, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Παύλος Μαραγκουδάκης, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ευθύμιος Κυροδήμος, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Οδυσσέας Ανδρούτσος, Αναπληρωτής Καθηγητής, Τμήμα Διατροφής και Διαιτολογίας, Πανεπιστήμιο Θεσσαλίας
Original Title:
Η επίδραση της διατροφής της εμπλουτισμένης με αντιοξειδωτικά στη θεραπευτική αντιμετώπιση των ασθενών που πάσχουν από ιδιοπαθείς εμβοές των ώτων
Translated title:
The effect of antioxidant-enriched diet on the treatment of patients with idiopathic tinnitus
Summary:
Idiopathic subjective tinnitus is the perception of sound in the absence of any external stimulus, with no identifiable cause. Oxidative stress is possibly involved in its pathogenesis and a variety of antioxidant compounds have been studied as potential treatment approaches. The aim of the study was to explore the efficacy of antioxidant supplementation which provides vitamins, minerals and phytochemicals combined with a-lipoic acid on tinnitus parameters and subjective discomfort in idiopathic tinnitus patients. A second aim was to assess whether antioxidant administration had an impact on biomarkers of oxidative stress and antioxidant capacity.
This is a randomized, double-blind, placebo-controlled clinical trial. Patients (N= 70) were randomly allocated to antioxidant supplementation (N=35) or to placebo (N=35) for a total of 3 months. Demographic, anthropometric, clinical and nutritional data were collected. Tinnitus loudness, frequency and Minimum Masking Level (MML), scores in Tinnitus Handicap Inventory questionnaire (THI), Tinnitus Functional Index (TFI) and Visual Analogue Scale (VAS) and Serum Total Antioxidant Capacity (TAC), oxidized LDL (ox.LDL) and Superoxide Dismutase (SOD), were evaluated at baseline and follow-up.
Results from psychoacoustic measurements of tinnitus revealed that loudness and MML significantly decreased from baseline to post measure (p<0.001) only in the antioxidant group and the overall change was different between the two groups as indicated from the significant interaction effect of the analysis (p<0.001). Tinnitus frequency did not significantly change in any of the two groups. Results from the tinnitus questionnaires before and after the intervention revealed that scores of THI, VAS, TFI-Relaxation (TFI-R) and TFI-Emotions (TFI-E) had a significant reduction in the antioxidant group, while no change was recorded in the placebo group. A significant interaction effect of group with time indicated a significant treatment difference for THI, TFI-R and TFI-E. Moreover, there was a significant decrease in the auditory threshold at the frequencies of 250 Hz, 500 Hz, 1000 Hz, 2000 Hz and 6000 Hz only in the antioxidant group whereas in the placebo group there was no significant change post intervention. As far as serum concentrations of biomarkers of oxidative stress and antioxidant capacity are concerned, serum TAC was decreased significantly in both groups, while SOD and ox.LDL did not change in either of the two groups. Differences between the groups in changes in serum TAC, SOD and oxLDL postintervention were insignificant.
Results of this study showed that antioxidant supplementation with vitamins, minerals, phytochemicals and ALA could exhibit favourable effects in tinnitus by reducing the subjective discomfort and tinnitus intensity. However, the effect of the antioxidant supplementation in oxidative stress biomarkers in tinnitus patients needs further investigation.
Main subject category:
Health Sciences
Keywords:
Tinnitus, Idiopathic tinnitus, Antioxidants
Number of references:
274
