Unit:
Κατεύθυνση Μοριακή και Εφαρμοσμένη ΦυσιολογίαLibrary of the School of Health Sciences
Author:
Molympakis Aristeidis
Supervisors info:
Ελένη Κοτσιφάκη, Αναπληρώτρια Καθηγήτρια, Εργαστήριο Πειραματικής Φυσιολογίας, Ιατρική Σχολή Πανεπιστημίου Αθηνών. (επιβλέπουσα).
Μιχάλης Κουτσιλιέρης, Καθηγητής, Εργαστήριο Πειραματικής Φυσιολογίας, Ιατρική Σχολή Πανεπιστημίου Αθηνών.
Γεώργιος Βαϊόπουλος, Ομότιμος Καθηγητής Παθολογίας, Ιατρική Σχολή Πανεπιστημίου Αθηνών.
Original Title:
Μελέτη των βιοδεικτών που σχετίζονται με την αθηρωμάτωση. Ο ρόλος της συστηματικής φλεγμονής στην έναρξη και εξέλιξη της ενδοθηλιακής δυσλειτουργίας και των αθηρωματικών βλαβών.
Translated title:
Approaching biomarkers related to atherosclerosis. The role of systemic inflammation in the onset and progression of endothelial dysfunction and atherosclerotic lesions.
Summary:
Inflammation plays an integral role in the onset and progression of atherosclerosis. Endothelial dysfunction, the accumulation of oxidized lipids in the sub endothelial space and the induced involvement of innate and adaptive immunity are key points for disease progression. Increased inflammatory load, in the presence of systemic inflammatory diseases, such as rheumatoid arthritis and psoriasis, adversely affects the development of atherosclerosis, as it induce earlier onset, more severe progression and an increased number of complications. Existing assessment methods often fail to predict future cardiovascular risk in patients with underlying inflammatory conditions. The combined use of those methods, with the levels of pro-inflammatory cytokines such as IL-6, TNF-α and the more widely, best studied and easy to use in daily clinical practice hsCRP, could provide important data in assessing disease activity and control, as well as in recalculating future cardiovascular risk. Studies such as CANTOS, JUPITER, ATHEROMA and CIRT provide important evidence of the impact of systemic inflammation on the atherosclerotic process and its complications. The administration of antilipidemic agents of statins, with their pleiotropic anti-inflammatory effects, appear to play an important role in the reduction of future cardiovascular risk by providing better control over both cholesterol levels and systemic inflammatory diseases.
Main subject category:
Health Sciences
Keywords:
Atherosclerosis, Inflammation, Biomarkers, Arthritis, Psoriasis
Number of references:
619
