Κατεύθυνση Βιοστατιστική
Library of the School of Health Sciences

2020-06-17

2020

Psallida Panagiota

Γιαννούτσος Κωνσταντίνος, Καθηγητής(επόπτης), Τμήμα Ιατρικής, Πανεπιστήμιο Ιντιάνα
Καρλής Δημήτριος, Καθηγητής, Τμήμα Στατιστικής, Οικονομικό Πανεπιστήμιο Αθηνών
Μπακογιάννης Γεώργιος, Επίκουρος Καθηγητής, Τμήμα Ιατρικής, Πανεπιστήμιο Ιντιάνα

Factors affecting disengagement from care and death while on Antiretrovial Therapy (ART)

English

Factors affecting disengagement from care and death while on Antiretrovial Therapy (ART)

The main goal of this cohort study was to explore and describe the determinant factors affecting adherence to antiretroviral treatment (ART) among patients infected with the Human Immunodeficiency Virus (HIV). To address this, prior work has used statistical methodologies of survival data with competing risks, such as the semi-parametric proportional cause-specific hazards model with missing at random cause of failure. However, the important problem in resource-limited settings, and especially in sub-Saharan Africa (SSA), is the significant under-reporting of the death of patients. This can lead to seriously biased effect estimates of potential predictors of a) death while in care, b) disengagement from care, and c) transfer to another site. In this paper, we use a double-sampling design where a subset of patients that have been flagged as lost to clinic are traced in the community, and their vital status is actively ascertained. Then, we apply a special statistical methodology in order to adjust estimates in the entire population receiving HIV care and treatment services to deal with the missing data problems.

Health Sciences

Cause-specific hazard, Cumulative incidence function, Missing data, Double-sampling design, Antiretroviral therapy, Adherence, Determinant factors, HIV infection

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https://pergamos.lib.uoa.gr/uoa/dl/object/2916778