Κατεύθυνση Διαταραχές της αναπνοής στον ύπνο - Εργαστηριακή και Κλινική Ιατρική του Ύπνου
Library of the School of Health Sciences

2020-07-20

2020

Dimopoulou Christina

Σπυρίδων Ζακυνδινός, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Κατσαούνου Παρασκευή, Επίκουρη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Λουτράρη Ελένη, ΕΔΙΠ, Ιατρική Σχολή, ΕΚΠΑ

Αποφρακτκή Υπνική Άπνοια και Σακχαρώδης Διαβήτης

Greek

Obstuctive Sleep Apnoea and Diabetes Mellitus

Diabetes mellitus (DM) is a chronic disease that emerges as a 21 century pandemic. There are two types of DM: Type 1 DM (T1DM) is characterized by the destruction of pancreatic β-cells and Type 2 (T2DM) by the relative lack of insulin and/or insulin resistance. About 90-95% of people with DM have Type 2 . Obesity and physical inactivity are major risk factors for the development of T2DM. Obstructive Sleep Apnoea (OSA) is a common and serious disorder that is increasingly recognised in overweight and obese people. Studies suggest that OSA independent of obesity is associated with insulin resistance and glucose intolerance. In recent years, various possible mecchanisms have been reported linking OSA with glucose metabolism. It is common for people with T2DM to also have OSA and the severity of OSA is associated with poorer glucose control. However, it is not clear wether OSA is causal in the development of DM or if treatment with continuous positive airway pressure (CPAP) has a fa favourable effect on glucose metabolism. Here we review the relationship between OSA and DM (mainly T2DM), the potential molecular mechanisms and the effect of CPAP on glycemic control in patients with OSA and DM.

Health Sciences

Apnoea, Obstructive sleep, Diabetes mellitus, Insulin, Glucose metabolism

No

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Yes

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https://pergamos.lib.uoa.gr/uoa/dl/object/2920063