Unit:
Κατεύθυνση Αποκατάσταση Βλαβών Νωτιαίου Μυελού. Διαχείριση του πόνου Σπονδυλικής προέλευσηςLibrary of the School of Health Sciences
Author:
Alexoudis Andreas
Supervisors info:
Ευαγγελοπούλου Ελευθερία-Μαρία, Επικ.Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Βλάμης Ιωάννης, Επικ.Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ευαγγελόπουλος Δημήτριος-Στέργιος, Ακαδημαϊκός Υπότροφος, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Ο ρόλος των φλεγμονωδών κυτταροκινών στην αποκατάσταση βλάβης μετά από κάκωση νωτιαίου μυελού: Ο ρόλος του NF-κΒ. Νεότερα δεδομένα
Translated title:
The role of infammatory cytokines in the recovery of spinal cord injury. Resent data on NF-kB
Summary:
Spinal cord injury is damage to the spinal cord, resulting from physical trauma as well as
other pathological conditions, causing temporary or permanent changes in its function.
SCI demonstrates increased mortality and morbidity placing a great financial burden to
health systems worldwide. The physiology of post-injury spinal cord recovery is
complicated and includes primary and secondary damage mechanisms. Inflammation and
inflammatory cytokines hold a central role in this procedure. This is a review of the existing
literature on the role of inflammatory cytokines in the recovery process following spinal
cord injury, with emphasis on the role of the transcriptive factor NF-κΒ. NF-κΒ is the
ultimate signalling molecule in pathophysiological mechanisms regulated by inflammatory
cytokines, such as TNF-α and IL-1β. Its activation includes a complicated network of
pathways that interact with one another through several checkpoints. NF-κΒ modification
influences gene expression in the post-injury spinal cord and regulates intracellular
procedures that mediate the recovery of the neuronal tissue. These procedures include
inflammation, cellular death, oxidative stress and myelination of neuraxons. Therapies that
affect NF-Κβ mediated pathways influence the functionality and the prognosis of patients
who have sustained a spinal cord injury.
Main subject category:
Health Sciences
Keywords:
Spinal cord injury, Recovery, Cytokines, NF-κΒ
Number of references:
153
