Unit:
Κατεύθυνση Ιατρική Φυσική-ΑκτινοφυσικήLibrary of the School of Health Sciences
Author:
Anestis Dimitrios
Supervisors info:
Αλέξανδρος Γεωργακίλας, Αναπληρωτής Καθηγητής, Σχολή Εφαρμοσμένων Μαθηματικών και Φυσικών Επιστημών, ΕΜΠ, Επιβλέπων
Δημήτριος Εμφιετζόγλου, Καθηγητής, Τμήμα Ιατρικής, Πανεπιστήμιο Ιωαννίνων
Παντελής Καραΐσκος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Modelling of cellular survival using Monte Carlo Damage Simulation Algorithm
Translated title:
Modelling of cellular survival using Monte Carlo Damage Simulation Algorithm
Summary:
This study focuses on the calculation of cellular survival of mammalian cells after irradiation. Double strand breaks are considered the most lethal damage to be induced on a cell. The NHEJ repair pathway is the predominant repair mechanism of DSBs for cells at G1/S phase on cell cycle. A mechanistic model was used to quantify cellular survival as well as other important radiobiological parameters, i.e. RBE, α/β ratio and OER.
The model consists of two input parameters, the average number of primary particles which caused DSBs and the average number of DSBs yield, obtained with MCDS and six fitting parameters that describe biological characteristics of the irradiated cells during the repair process.
Following the estimation of these parameters, the model is applied on further experimental results concerning V79 cells after proton and carbon ions irradiation. The capability of the model to simulate cellular survival and RBE is partly sufficient, while the impact of molecular oxygen on damage induction is hardly indistinguishable.
Main subject category:
Health Sciences
Keywords:
Monte Carlo, Cellular survival
