Unit:
Faculty of MedicineLibrary of the School of Health Sciences
Author:
Stylianaki Aikaterini
Dissertation committee:
Δημήτριος Δημητρούλης, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ, Επιβλέπων
Γεώργιος Ζωγράφος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Απόστολος Παπαλόης, Διευθυντής Ερευνητικού Εργαστηρίου ΕΛΠΕΝ,
Καθηγητής του Πανεπιστημίου Κύπρου
Κωνσταντίνος Κόντζογλου, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Νικόλαος Αρκαδόπουλος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Φλώρα Ζαγουρή, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Νικόλαος Μιχαλόπουλος, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Μορφολογική, βιοχημική και μοριακή μελέτη της προστατευτικής δράσης των μορίων U-74389G (λαζαροειδές), της ερυθροποιητίνης, της σιλδεναφίλης και της οκτρεοτίδης, στην συντήρηση καρδιάς-πνευμόνων για μεταμόσχευση
Translated title:
Morphological, biochemical and molecular study of the beneficial effect of molecules U-74389G (lazaroid), erythropoietin, sildenafil and octreotide in the preservation of heart/lung graft for transplantation
Summary:
One of the challenges in the field of organ transplantation is effective transplant preservation during the donor/recipient time interval. In order to examine and potentially improve the efficacy of the existing preservation solutions in heart /lung transplantation, we studied four different pharmaceutical agents (erythropoietin, sildenafil, lazaroid, Octreotide) as enrichment of the University of Wisconsin solution and intravenous organ pretreatment. We conducted a double-blind animal study using 56 Landrace pigs, divided in groups of 6, receiving accordingly one of the fouragents as iv-pretreatment and as enrichment of the U.W. solution. The organs were studied at three different time points (organ procurement, 8 and 24 hours post organ procurement) conducting histopathological, serum, and oxidative-stress assessment. Interstitial edema disappeared in lung 8 hours post organ procurement after Erythropoietin and lazaroid treatment. We draw the conclusion that pharmacologically modified preservation solutions could prevent recent transplant rejection.
Main subject category:
Health Sciences
Keywords:
Ischemia reperfusion injury, Preservation solutions, Heart-lung transplantation, University of Wisconsin Solution
Number of references:
166
