Unit:
Κατεύθυνση Έρευνα στην Γυναικεία ΑναπαραγωγήLibrary of the School of Health Sciences
Author:
Kardalas Efstratios
Supervisors info:
Γεώργιος Μαστοράκος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Djuro Macut, Καθηγητής, Ιατρική Σχολή, Πανεπιστήμιο Βελιγραδίου
Marek Ruchala, Καθηγητής, Ιατρική Σχολή, Πανεπιστήμιο Επιστημών Υγείας του Πόζναν
Original Title:
Transforming Growth Factor β (TGF-β), a master regulator of thyroid autoimmunity; what do we know and what can we hope for the future; a review
Translated title:
Transforming Growth Factor β (TGF-β), a master regulator of thyroid autoimmunity; what do we know and what can we hope for the future; a review
Summary:
In this article, we review the significant role of Transforming Growth Factor beta (TGF-β) in the development, evolution, and treatment of thyroid autoimmunity. We first examine the pathophysiology of thyroid autoimmunity in various associated pathological conditions, then the generation and activation of TGF-β, the significance of its action and its important role regarding the immune system. We then examine the defects in TGF-β observed thus far in autoimmune thyroid diseases (Grave’s disease and Hashimotos’ thyroiditis), thyroid-associated orbitopathy, autoimmune thyroid disease in pregnancy and post-partum thyroiditis and the central role of TGF-β in the pathophysiology and development of the whole spectrum of thyroid autoimmunity. Finally, we point to possible clinical applications involving TGF-β as a prognostic factor and a therapeutic target for thyroid autoimmunity and future perspectives.
Main subject category:
Health Sciences
Keywords:
TGF-β, Autoimmune thyroid diseases, Thyroid gland, Immune cells, Thyroiditis
Number of references:
117
