Unit:
Κατεύθυνση Οργανική Σύνθεση και Εφαρμογές της στη Χημική ΒιομηχανίαLibrary of the School of Science
Author:
Mavrikaki Vasiliki
Supervisors info:
Βικτωρία Μαγκριώτη, Αναπλ. Καθηγήτρια, Τμήμα Χημείας, Ε.Κ.Π.Α.
Original Title:
Σχεδιασμός, Σύνθεση και Αντιμυκοβακτηριδιακή Δράση Υδροξαμικών Οξέων και Υδραζιδίων Υποκατεστημένων Κινναμωμικών Οξέων και (2E,4E)-5-Φαινυλοπεντα-2,4-διενοϊκών Οξέων
Translated title:
Design, Synthesis and Antifungal Activity of Hydroxamic Acids and Hydrazides of Substituted Cinnamic Acids and (2E,4E)-5-Phenylpenta-2,4-dienoic Acids
Summary:
In the present thesis, hydroxamic acids, their derivatives and hydrazides are discussed, as well as their anti-tuberculosis activity. The first chapter presents Mycobacterium Tuberculosis, the modern diagnostics and treatment methods that are currently being used against tuberculosis. Furthermore, resistant forms of tuberculosis are reported and the need to find new drugs is emphasized. The biological activity of hydroxamic acids, cinnamic acids and hydrazides, along with the general methods of their synthesis are described in the next chapter. The second part analyzes the design and synthesis of hydroxamic acids, substituted hydroxamic acids and hydrazides, analogues of isoniazid, one of the first-line drugs for the treatment of tuberculosis. Finally, the procedures and characterizations of these compounds are presented.
Main subject category:
Science
Keywords:
Antimycobacterial activity, cinnamic acids, hydrazides, hydroxamic acids, tuberculosis
Number of index pages:
15
Number of references:
121
