Unit:
Specialty NanomedicineLibrary of the School of Health Sciences
Supervisors info:
Κωνσταντίνος Δεμέτζος, Καθηγητής, Τμήμα Φαρμακευτικής, ΕΚΠΑ (επιβλέπων)
Μαριλένα Βλάχου, Αναπληρώτρια Καθηγήτρια, Τμήμα Φαρμακευτικής, ΕΚΠΑ
Ευάγγελος Καραλής, Επίκουρος Καθηγητής, Τμήμα Φαρμακευτικής, ΕΚΠΑ
Original Title:
Evaluation of nano-systems as vaccine platforms against infectious diseases
Translated title:
Evaluation of nano-systems as vaccine platforms against infectious diseases
Summary:
Vaccines are one of the most important pages of human health by providing protection against various infections. Although the indisputable benefits of classic vaccines, they have some serious limitations such as low immunogenicity and short-term effectiveness, time-consuming developing and/or manufacturing processes, high cost, and limited variety of administration routes and storage. The above led to the development of nanovaccinology, a science area which concludes vaccine platforms of 1-1000 nm. These platforms function either as antigen delivery systems or as immune-stimulators that induce both innate and adaptive immune responses. Nanovaccines can be classified by their physicochemical and morphological characteristics and, thus, platforms with unique properties are able to form. Liposomes, virus-like particles, nano-emulsions, polymeric or inorganic nanoparticles as well as viral vectors are the main categories that are currently on the market or in clinical and pre-clinical phases. Nano-formulations allow the manufacture of innovative vaccines, such as the third generation vaccines, but they shall be carefully studied to minimize probable dangers from their use in clinical practice. Medicine Agencies are responsible for composing a legislative framework about nanovaccinology. In this way, both pharmaceutical companies and human populations will be benefited by eliminating the danger of upcoming pandemics or other infectious diseases.
Main subject category:
Health Sciences
Keywords:
Nano-vaccine, Antigen delivery system, Adjuvant, Immunology, Virus, Infection
Number of references:
262
