Κατεύθυνση Αναπαραγωγική-Αναγεννητική Ιατρική
Library of the School of Health Sciences

2020-10-21

2020

Kyriaki Stamatia

Δρακάκης Πέτρος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ντόμαλη Αικατερίνη, Επίκουρη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Μαυρογιάννη Δέσποινα, ΕΔΙΠ, Ιατρική Σχολή, ΕΚΠΑ

Έκφραση microRNA-27a στα κοκκώδη κύτταρα σε πληθυσμό γυναικών IVF/ICSI

Greek

ΜicroRNA-27a expression in granulosa cells in women undergoing IVF / ICSI procedures

Infertility nowadays is a burning topic of discussion and research. The fields that have begun to be studied are many and employ a large part of the research community. In the present study, the effect of miRNA-27a (miR-27a) expression on ovarian granulosa cells was studied, as well as its association with general infertility characteristics and the response of women to infertility treatments. According to the results, moderate to low expression of the studying gene was found. Attempts to correlate these results with infertility data did not result in any significant correlation, which may be due to the small number of samples. However, there are apoptotic mechanisms associated with apoptosis of granulosa cells and various miRNAs including miR-27a. Further study of this relationship may suggest a correlation between the expression of miR-27a, and consequently other miRNAs, in granulosa cells and the effect on a woman's fertility generally.

Health Sciences

MicroRna-27a, Granulosa cells, Infertility, Apoptosis, Gene expression

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Yes

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https://pergamos.lib.uoa.gr/uoa/dl/object/2925634