Unit:
Faculty of MedicineLibrary of the School of Health Sciences
Author:
Iordanou Christos
Dissertation committee:
Δημήτριος Δημητρούλης, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ, Επιβλέπων
Γεώργιος Ζωγράφος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Απόστολος Παπαλόης, Αναπληρωτής Καθηγητής, Πανεπιστήμιο Κύπρου
Ευάγγελος Μενενάκος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Σπυρίδων Στεργιόπουλος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Κωνσταντίνος Αλμπανόπουλος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Φλώρα Ζαγουρή, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Μορφολογική, βιοχημική και μοριακή μελέτη της προστατευτικής δράσης των μορίων U-74389G (Λαζαροειδές), της Ερυθροποιητίνης, της Σιλδεναφίλης και της Οκτρεοτίδης, στη συντήρηση παγκρέατος για μεταμόσχευση
Translated title:
Morphological, biochemical and molecular study of the beneficial effect of molecules U-74389G (lazaroid), erythropoietin, sildenafil and octreotide in the preservation in preservation of the pancreas for transplantation.
Summary:
One of the challenges in the field of organ transplantation is effective transplant preservation during the donor/recipient time interval. In order to examine and potentially improve the efficacy of the existing preservation solutions in pancreatic transplantation, we studied four different
pharmaceutical agents (erythropoietin, sildenafil, lazaroid, Octreotide) as enrichment of the
University of Wisconsin solution and intravenous organ pretreatment before retrieval. We conducted a double-blind animal study using 54 Landrace pigs, divided in groups of 6, receiving accordingly one of the fouragents as iv-pretreatment and as enrichment of the U.W. solution. The organs were studied at three different time points (organ procurement, 8 and 24 hours post organ procurement) conducting histopathological, serum, and oxidative-stress assessment. According to our results, the four pharmacological agents were shown beneficial dynamics for serum and istological parameters like MDA, TNF-a, oedema or hemorrhage which seems to be important in ischemia/reperfusion injury of the pancreas during the transplantation procedure. We draw the conclusion that the idea of pharmacologically modified preservation solutions and management could improve the quality of the organs for transplantation and also could prevent recent transplant rejection. Of course, more experimental investigation and clinical evidences are needed, before a good idea will be ready to become true and beneficial for our patients.
Main subject category:
Health Sciences
Keywords:
Pancreas, Transplantation, Preservation, Lazaroid, Sildenafil, Erythropoietin, Octreotide
Number of references:
236
