Unit:
Faculty of MedicineLibrary of the School of Health Sciences
Author:
Alexandrou Paraskevi
Dissertation committee:
Εμμανουήλ Αγαπητός, Ομότιμος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ, Επιβλέπων
Νικόλαος Καβαντζάς, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ανδρέας Χ.Λάζαρης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Χαρίκλεια Γακιοπούλου, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Μιχαήλ Καραμόυζης, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Γεώργιος Αγρογιάννης, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ειρήνη Θυμαρά, Επίκουρη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Η κλινική σημασία της έκφρασης της πρωτεΐνης HuR στο μη μικροκυτταρικό καρκίνωμα πνεύμονα
Translated title:
The clinical significance of HuR protein expression in non- small cell lung carcinoma
Summary:
Hu-antigen R (HuR) is considered to play a central role in tumor formation, growth, and metastasis by binding to messenger RNAs (mRNAs) encoding proteins such as cyclooxygenase- 2 (COX-2) and inducing their expression via mRNA stabilization and/or altered translation. The present study aimed to evaluate the clinical significance of HuR and COX-2 protein expression in non-small-cell lung carcinoma (NSCLC). HuR and COX-2 expression was assessed immunohistochemically on tissue microarrays of 81 surgically resected NSCLC and was analyzed in relation with clinico- pathological characteristics and patients’ survival. Enhanced total HuR expression was significantly associated with tumor histological type and presence of lymph node metastases, as well as with increased tumor proliferative capacity and poor patients’ outcome (p=0.039, p=0.017, p=0.033, and p= 0.022, respectively). Enhanced COX-2 expression was significantly associated with the presence of lymphovascular invasion and increased tumor proliferative capacity (p = 0.031 and p = 0.023, respectively). Concomitant elevated HuR/ COX- 2 expression levels were significantly associated with tumor histological type and increased proliferative capacity (p = 0.002 and p = 0.045, respectively). Enhanced total HuR expression, as well as its cytoplasmic localization, was signif- icantly associated with increased COX-2 expression (p = 0.015 and p = 0.001, respectively). The present study supported ev- idence that HuR may participate in malignant transformation of NSCLC, reinforcing its usefulness as potential therapeutic target in this type of neoplasia.
Main subject category:
Health Sciences
Keywords:
HuR protein, Non-small cell lung carcinoma, Prognosis, Molecular classification, Survival
Number of references:
152
