Unit:
Κατεύθυνση Κλινικοπαθολογοανατομική θεώρηση των νεοπλασιών του ανθρώπουLibrary of the School of Health Sciences
Supervisors info:
Λάζαρης Ανδρέας Χ., Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Γακιοπούλου Χαρά, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Γιαννοπούλου Ιωάννα, Ε.ΔΙ.Π., Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Επιγενετικές αλλαγές στο ουροθηλιακό καρκίνωμα της ουροδόχου κύστης
Translated title:
Epigenetic modifications of the urothelial carcinoma of the bladder
Summary:
Urothelial carcinoma is the most common neoplasia of the bladder. Due to its high incidence, prevalence, recurrence and mortality, it remains an unsolved clinical and social problem. Epigenetic changes, such as aberrant DNA methylation and histone modification, aberrant chromatin remodeling, and deregulated expression of non-coding RNAs, occur predominantly in urothelial carcinoma and may be “driver” changes towards pathogenesis and progress of the disease. Therefore, an attempt is made to use these epigenetic modifications as potential biomarkers, which would be hopefully considered as therapeutic targets for future treatment of urothelial cancer. In this review, we summarize recent findings in these emerging aspects, and shed light on such an important, ultimately, epigenome, with a view to its use in the future clinical treatment of the disease.
Main subject category:
Health Sciences
Keywords:
Epigenomics, DNA, Urothelial carcinoma, Bladder cancer, Epigenetic changes, Chromatin, Histone modifications, DNA methylation, miRNAs, RNAs, Biomarkers, Epigenetic therapy
