Unit:
Specialty NanomedicineLibrary of the School of Health Sciences
Author:
Patsoura Elisavet
Supervisors info:
Ευσταθόπουλος Ευστάθιος, Καθηγητής , Ιατρική Σχολή, ΕΚΠΑ
Μουζάκης Διονύσιος, Καθηγητής, Στρατιωτική Σχολή Ευελπίδων
Λαγοπάτη Νεφέλη, Μεταδιδακτορική Ερευνήτρια, ΕΜΠ
Original Title:
Biologic effects of inoganic Titanium Nanoparticles in ocular surface pathology
Translated title:
Biologic effects of inoganic Titanium Nanoparticles in ocular surface pathology
Summary:
Titanium dioxide is abundant in nature and has found wide use in a variety of applications. TiO2 nanoparticles’ small size is responsible for their unique physicochemical properties. Nanoparticles have demonstrated superb antimicrobial efficacy due their photocatalytic properties. They have also been tried as a photosensitiser for photodynamic therapy of various tumor cells. Activation of the nanoparticles with light has been a prerequisitive for reactive oxygen species production that are responsible for
cell distruction. Photoactivated titanium dioxide has been effective against various microorganisms including gram positive, gram negative bacteria, fungi and protozoa, providing an alternative treatment modality in view of the evolution of antibiotic resistant microorganisms. Ocular surface infections such as corneal ulcers can potentially have a devastating impact on vision and ocular integrity. UVA activated TiO2 can become a promising adjunctive treatment to accomplish faster disinfection and recovery. Ocular surface neoplasias can also present a treatment challenge due to their recurrence rate as well as the difficulty to be completely excised at healthy margins. Photoactivated TiO2 can be helpful in reducing tumor size or even as a sole treatment to small tumors. Nevertheless the issue of toxicity remains. The ocular surface can sustain UVA irradiation of relatively high dose as known from various existing ophthalmic treatments. Topical, intraoular and systemic absorption of the nanoparticles cannot be ignored. Several studies have reported the toxic effects of TiO2 on ocular tissues as well as brain and other organs where they can reach through various routes. Although promising, treatment parameters have to be carefully studied and potential ways for toxicity to be eliminated need to be explored so that TiO2 can find use in ocular surface diseases.
Main subject category:
Health Sciences
Keywords:
Titanium oxide nanoparticles, Phototocatalysis, Microbiocidal, Tumor,Toxicity, Ocular surface
Number of references:
130
