Unit:
Κατεύθυνση Χειρουργική ΟγκολογίαLibrary of the School of Health Sciences
Author:
Marinis Athanasios
Supervisors info:
Θεοδόσιος Θεοδοσόπουλος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ, Επιβλέπων
Γεώργιος Φραγκουλίδης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Κωνσταντίνος Γ. Τούτουζας, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Η έκφραση του συνδέτη του μορίου προγραμματισμένου κυτταρικού θανάτου PD-L1 (programmed cell death ligand-1) στον κολο-ορθικό καρκίνο
Translated title:
The expression of PD-L1 (programmed cell death ligand-1) in colorectal cancer
Summary:
Introduction: The development of new therapeutic agents aiming at pathways of the immune system seem to change the treatment of several cancers. Five immune check-points have been found as possible targets of immunotherapy: the programmed cell death molecule PD-1, its ligand PD-L1, cytotoxic T-lymphocyte associated protein 4 (CTLA4), the lymphocyte activation gene (LAG-3) and indoleamine 2,3-dioxygenase (IDO).
Aim: To study the expression of PD-L1 in histological specimens of gastric and colorectal cancers.
Methods: The expression of PD-L1 was measured with a standardized immunohistochemical method and was categorized in three levels: a) expression < 1% (absence of expression), b) expression 1-49% (low expression), and c) expression > 50% (high expression). All specimens of gastric cancers were negative for expression of PD-L1 and were not included finally in this study.
Results: Thirty-two (32) specimens of patients with colorectal cancer were studied, 16 males and 16 females, with a medium age of 71,4 years (45-93). Histologically, most cancers were moderately differentiated (24) and the remaining (8) were poorly differentiated. Expression of PD-L1 was absent in 21 patients (65,6%), low in 5 (15,6%) and high in 6 patients (18,75%). All patients with a high expression of PD-L1 expressed high microsatellite instability (MSI-high).
Conclusion: High expression of PD-L1 is usually associated with high microsatellite instability in patients with colorectal cancer.
Main subject category:
Health Sciences
Keywords:
PD-1, PD-L1, Colorectal cancer, Gastric cancer, Immunotherapy
