Κατεύθυνση Ογκολογία Θώρακα: Σύγχρονη Κλινικο-Εργαστηριακή Προσέγγιση και Έρευνα
Library of the School of Health Sciences

2021-01-26

2021

Giannikou Kannela

Κωνσταντίνος Ν. Συρίγος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Μαρία Καγιά, Διδάκτωρ, Ιατρική Σχολή, ΕΚΠΑ
Ιωάννης Τουρκαντώνης, Διδάκτωρ, Ιατρική Σχολή, ΕΚΠΑ

Νευροπάθεια απότοκος χημειοθεραπείας - νεότερα δεδομένα στη διάγνωση και αντιμετώπιση

Greek

Chemotherapy induced peripheral neuropathy - updates on diagnosis and treatment

Introduction: One of the most important side effects of chemotherapy is neurotoxicity. The prevention and successful treatment of chemotherapy induced peripheral neuropathy (CIPN) is especially important, as neurotoxicity affects the patient physically and functionally and worsens his quality of life.
Aim: To investigate the interventions related to the prevention or treatment of CIPN in cancer patients, through the review of the international literature.
Methodology: The international literature was searched, in July - August 2020, in the electronic databases of Pubmed, Cinahl and Scopus with the following keywords "chemotherapy-induced peripheral neuropathy", "cancer", "treatment" and "prevention" . The review included randomized clinical trials written in English and published from 01/01/2010 to 31/08/2020 concerning interventions to prevent or treat CIPN in adult patients diagnosed with cancer and receiving chemotherapy.
Results: The review included 24 articles, of which 13 relate to non-pharmaceutical interventions. Αll-trans retinoic acid (ATRA), gabapentin, duloxetine, Calmangafodipir and BALKO topical gel are associated with reduced CIPN and improved neurotoxicity symptoms. Regarding non-pharmacological interventions, acupuncture, exercise, reflexology and photovimilization were found to be associated with improved CIPN symptoms. Finally, factors that were found not to significantly improve the symptoms of neuropathy compared to the control group are vitamin E, vitamin B, alpha-lipoic acid, glutathione, cryotherapy and the herb goshajinkigan
Conclusions: In conclusion, therefore, pharmaceutical, and non-pharmaceutical agents can contribute to the prevention and successful treatment of the symptoms of neuropathy that is the result of chemotherapy.

Health Sciences

Chemotherapy-induced periphery neuropathy, Prevention, Treatment, Cancer

Yes

2

Yes

67

127

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https://pergamos.lib.uoa.gr/uoa/dl/object/2933640