Κατεύθυνση Έρευνα στην Γυναικεία Αναπαραγωγή
Library of the School of Health Sciences

2021-03-24

2021

Barlampa Danai

Μαστοράκος Γεώργιος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Βαλσαμάκης Γεώργιος, Διδάκτωρ, Ιατρική Σχολή, ΕΚΠΑ
Καλανταρίδου Σοφία, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ

Υποθαλαμική φλεγμονή ως κοινό παθοφυσιολογικό αίτιο της ετερογένειας των συμπτωμάτων του συνδρόμου πολυκυστικών ωοθηκών

Greek

Hypothalamic Inflammation as a Potential Pathophysiologic Basis for the Heterogeneity of Clinical, Hormonal, and Metabolic Presentation in PCOS

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age. It is a heterogeneous condition characterized by reproductive, endo-crine, metabolic, and psychiatric abnormalities. More than one pathogenic mechanism is involved in its development. On the other hand, the hypothalamus plays a crucial role in many important functions of the body, including weight balance, food intake, and reproduction. A high-fat diet with a large amount of long-chain saturated fatty acids can induce inflammation in the hypothalamus. Hypothalamic neurons can sense extracellular glucose concentrations and participate, with a feed-back mechanism, in the regulation of whole-body glucose homeostasis. When consumed nutrients are rich in fat and sugar, and these regulatory mechanisms can trigger inflammatory pathways re-sulting in hypothalamic inflammation. The latter has been correlated with metabolic diseases, obe-sity, and depression. In this review, we explore whether the pattern and the expansion of hypotha-lamic inflammation, as a result of a high-fat and -sugar diet, may contribute to the heterogeneity of the clinical, hormonal, and metabolic presentation in PCOS via pathophysiologic mechanisms af-fecting specific areas of the hypothalamus. These mechanisms could be potential targets for the de-velopment of effective therapies for the treatment of PCOS.

Health Sciences

High-fat diet, Nutrients overconsumption, Polycystic ovary syndrome, PCOS, Hypothalamic inflammation, Hypothalamus

No

0

Yes

182

67

File access is restricted only to the intranet of UoA.

https://pergamos.lib.uoa.gr/uoa/dl/object/2939909