Faculty of Medicine
Library of the School of Health Sciences

2021-04-07

2021

Stergiotis Stefanos

Μπάκα Σταυρούλα , Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ, Επιβλέπουσα
Λαμπρινουδάκη Ειρήνη, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Πανουλής Κωνσταντίνος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ελευθεριάδης Μακάριος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή , ΕΚΠΑ
Καπαρός Γεώργιος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Σταματελόπουλος Κίμων, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Πανοσκάλτσης Θεόδωρος, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ

Η συμβολή του Προεμμηνορυσιακού Συνδρόμου στη ρύθμιση της αρτηριακής ελαστικότητας και της αρτηριακής πίεσης

Greek

The contribution of Premenstrual Syndrome in the regulation of arterial stiffness and blood pressure

Introduction: Premenstrual Syndrome (PMS) is a common disorder of the menstrual cycle. It includes clinical manifestations (physical and emotional) that occur before and during menstruation, with different severity in each woman. The exact mechanisms behind its pathogenesis are not fully understood, however it seems to have a multifactorial cause. The physical symptoms of the syndrome may be related to mechanisms of increased inflammatory and oxidative stress. On the other hand, emotional symptoms also seem to aggravate the inflammatory process.
Aim: Since the process of atherosclerosis is related to all mentioned above, this study will examine the relationship that PMS may have with subclinical cardiovascular risk. The aim is to study the effect of premenstrual syndrome on the vascular function of women of reproductive age, taking in consideration the monthly changes in biochemical, hormonal, as well as structural and functional indicators of arterial elasticity and blood pressure in women with PMS and those without. At the same time, the relationship between the levels of Antimullerian Hormone (AMH) with subclinical atherosclerotic disease, was investigated.
Materials and Methods: The study involved 70 women of reproductive age 18 to 45 years, who responded positively to an announcement regarding hematological and angiological examination by the 2nd Obstetrics and Gynecology Clinic of the Aretaio Hospital of Athens. Two visits were made during the late follicular and luteal phase of their period. A complete personal and family medical history was obtained at the first visit. Their physical and mental symptoms were recorded, based on a questionnaire representing the Moos scale. The distinction between PMS and non-PMS women was based on diagnostic criteria from the University of California, San Diego. The diagnosis was made based on the presence of at least one physical and / or mental symptom and a difference of at least 30% in their intensity between the first and second visit was necessary. In both phases, biochemical, hormonal tests, anthropometric data were obtained and angiological indicators were measured by an experienced operator.
Results: The 70 women in the sample had a mean age of 32.7 ± 6.5 years. An inverse correlation was observed between Intima Media Thickness in all sections measured and the ln AMH. Thus the coefficient r and the p value for the Combined Carotid IMT, the IMT of the Common Carotid artery, the Carotid bulb, the Internal Carotid Artery and the FA were respectively: - 0.428 [p <0.001], -0.317 [p = 0.009] , -0.455 [p <0.001], -0.304 [= 0.012] and -0.312 [p = 0.010]. In addition, ln AMH levels were negatively correlated with total cholesterol r coeff. = - 0.273 [p = 0.029], LDL-C r coeff = - 0.262 [p = 0.037] and age r coeff = -0.435 [p <0.001] .17 No correlation was found with functional vascular indices. Finally, out of the 70 women who were initially introduced, only 64 of them returned to the second visit. Their classification showed that 48 of them were regarded as PMS and 16 as controls. The correlation of these two groups, in the two phases of the period, with the cardiovascular risk factors and all the other markers did not have any significant effect, except from prolactin, whose change was lower in the PMS group (+1.9 ng / mL) than in controls ( +6.5 ng / mL) [p = 0.032].
Conclusions: From the above data it is concluded that AMH levels are inversely related to the structural vascular indices of subclinical cardiovascular disease, while in women with PMS further investigation is needed, to clarify the role of lower prolactin levels compared to controls.

Health Sciences

Premenstrual syndrome, Arterial stiffness, AMH

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Yes

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https://pergamos.lib.uoa.gr/uoa/dl/object/2942547