Dissertation committee:
Δευτεραίος Σπυρίδων, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Παρίσης Ιωάννης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Λεκάκης Ιωάννης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ηλιοδρομίτης Ευστάθιος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Φιλιππάτος Γεράσιμος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ραλλίδης Λουκιανός, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Τούτουζας Κωνσταντίνος του Παύλου, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Summary:
Sudden cardiac death is a tragic event. One of the diseases that is directly associated with the occurrence of sudden cardiac death is Brugada syndrome. Since 1992, when this clinical entity was first described, much progress has been made in understanding the pathophysiological mechanisms of the syndrome, in diagnosis and in treatment. The implantation of a cardioverter-defibrillator remains to date the most effective therapeutic intervention to prevent sudden cardiac death. However, it is an intervention that is not devoid of long-term complications, which affect the morbidity and mortality of patients. The decision to implant a defibrillator depends directly on patient's risk of sudden cardiac death. As is obvious, the risk stratification is of major importance in the management and treatment of patients. In the literature there are different and conflicting data on the prognostic value of various clinical, electrocardiographic or electrophysiological markers and the specific field remains unclear. The present study concerns the stratification of arrhythmic risk of patients with Brugada syndrome with the aim of finding a multiparametric risk stratification model that will contribute to the optimization of the treatment of patients.
