Unit:
Faculty of MedicineLibrary of the School of Health Sciences
Author:
Angelina Afroditi
Dissertation committee:
Νικολέττα Ιακωβίδου, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Χρυσούλα Μπακούλα, Ομότιμη Καθηγήτρια,Ιατρική Σχολή, ΕΚΠΑ
Γεώργιος Γκιόκας, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Μπούτσικου Θεοδώρα, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Ηλιοδρομίτη Ζωή, Επίκουρη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Πανούλης Κωνσταντίνος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ξάνθος Θεόδωρος, Καθηγητής, Ιατρική Σχολή, Ευρωπαικό Πανεπιστημίου Κύπρου
Original Title:
Μελέτη της μεθόδου "των συνεχών θωρακικών συμπιέσεων" σε σύγκριση "με την αναλογία 3:1" στη νεογνική ασφυξία (πειραματική μελέτη)
Translated title:
Continuous chest compressions with asynchronous ventilation improve survival in a neonatal swine model of asphyxial cardiac arrest
Summary:
Introduction: Neonatal resuscitation is not only a major issue in scientific literature but it is also one that requires constant development for the survival of the neonate and the improvement of its neurological profile to the extent that this is possible. This has been the motive for the present research paper. The inquiring and comparison of two different methods of cardiopulmonary resuscitation on piglet model and its survival in any case.
Material and methods: Twenty piglet models were included in this study. The research protocol was separated in six phases: stabilization, cardiopulmonary arrest, return of spontaneous circulation (ROSC), observation and monitoring every 2 and 4 hours. All the animals suffered cardiopulmonary arrest, caused by asphyxia to the point that the heart rate dropped to 60pulses/minute or the MAP 15mmHg. Twenty neonate piglets were devided in two groups of ten, the control group and the intervention group. In the control group cardiopulmonary resuscitation was performed in an analogy 3:1 of chest compressions and infusions, while in the intervention group cardiopulmonary resuscitation was performed with continuous chest compressions and infusions, about 90 chest compressions and 30 infusions per minute during resuscitation until they resuscitated according to specific criteria such as heart rate at about 100/minute or MAP at 50 mmHg..
Results: Coronary perfusion pressure at the first 30 sec of CPR was higher in the experimental group (45.7±16.9 vs 21.8±6, p<0.001) and remained significantly elevated throughout the experiment. A statistically significant difference in diastolic aortic pressure was also noted between groups at 30 sec of CPR (50.6±17.5 vs. 25.8±6 in the experimental and control group, respectively, p<0.001). Furthermore, MAP was significantly higher in the experimental group (66.7±16.2 vs. 36.5±13, p<0.001). However, no difference was observed in right atrial pressure (4.9±1.2 vs. 4±1.4, p=0.14). Also, at 4 hours, 2 (20%) animals survived in the control group compared to 7 (70%) animals in the experimental group.
Conclusion: Continuous performance of chest compressions seems to take advantage as a method of neonate resuscitation when it comes to spontaneous recovery of circulation as well as the survival of the animal models during the four hours according to the present research protocol.
Main subject category:
Health Sciences
Keywords:
Neonatal resuscitation, Chest compressions, Neonatal ventilation
Number of references:
209
