Pregnancy and multiple sclerosis

Postgraduate Thesis uoadl:2944938 12 Read counter

Κατεύθυνση Παθολογία της Κύησης
Library of the School of Health Sciences
Deposit date:
Chatziioannou Leonardos
Supervisors info:
-Καλανταρίδου Σοφία, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
-Kασσάνος Δημήτριος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
-Βουμβουράκης Κωνσταντίνος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Κύηση και σκλήρυνση κατά πλάκας
Translated title:
Pregnancy and multiple sclerosis
Introduction - Purpose: Multiple sclerosis or multiple sclerosis (MS) is the most
common neurological disease that occurs in young adults, most of whom are women.
In the first half of the last century, there was a widespread view that pregnancy had a
negative effect on the course of the disease. Doctors advised patients not to go through
a pregnancy and very often suggested therapeutic abortion. In recent decades, it has
been widely believed that the risk of recurrence during pregnancy is lower and increases
during pregnancy.
Material - Method: The material of the work was extracted from International, Greek
bibliography and articles but also from the Internet using officially recognized sources.
Conclusions: Studies focusing on the short-term and long-term effects of pregnancy
on the progression of multiple sclerosis have shown that pregnancy is not associated
with disease exacerbation, during which recurrences rarely occur, and an increased
incidence of relapses after childbirth, especially in the first trimester. Pregnancy is a
period of remission of the symptoms of multiple sclerosis without knowing exactly the
mechanisms that lead to this remission. In contrast, one year after delivery needs special
attention due to an increased chance of recurrence. It is advisable to discontinue
immunomodulatory and immunosuppressive therapy before pregnancy.
Main subject category:
Health Sciences
Multiple sclerosis, Pregnancy, Flare-ups, Relapses, Immunomodulatory treatment
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