Supervisors info:
Κωνσταντίνος Τούτουζας,Αναπληρωτης Καθηγητής ,Ιατρική Σχολή,ΕΚΠΑ
Δημήτριος Τούσουλης ,Καθηγητής Καρδιολογίας,Ιατρική Σχολή,ΕΚΠΑ
Κυρίτση Ελένη,Ομότιμη Καθηγήτρια, Τμήμα Νοσηλευτικής, Πανεπιστήμιο Δυτικής Αττικής
Summary:
Severe aortic stenosis is the most common valve disease in elderly population, especially over 75 years old. Diagnosis is based mainly at a combination of clinical examination and of laboratory examination especially with the echocardiography report, while the prognosis of the disease depends on the reveal of symptoms.
The purpose of this study is to investigate the type and the frequency of clinical symptoms in patients with severe aortic stenosis before TAVI.
Material and method: An observational clinical trial was performed in which were included 50 patients who were treated in A’ Cardiology Department of Ippokrateion Hospital. At all patients were recorded the demographic characteristics and risk factors whilst the results of clinical-laboratory and imaging examination were recorded as well.
Results: Women were the 52,0% of the sample. The mean age of the patients were 80,4 years old (SD=7,6 years).All the patients has a concomitant disease , with the 42% of sample presented with two concomitant diseases while the 30% presented with three concomitant diseases. As concerns about the type of comorbilities, 56% of the sample presented with arterial hypertension, 36% have a history of atrial fibrillation, 24% concomitant renal disease while similar percentage were recorded at both coronary disease( 10%) and diabetes mellitus(14%).It was also found that 30% of the patients presented with symptoms of heart failure, 24% with symptoms of acute coronary syndrome while similar was the proportion of syncope and angina (12%).There were not a statistically significant correlation between cardiovascular events and demographic features of the patients p>0,05.While the percentage of patients with coronary disease had a statistically significant correlation between different cardiovascular events p=0,049.The mortality percentage which reaches 16%, is remarkable. Especially, 20.8% deaths were recorded at male population, whilst 11,5% were at female sample. Also, the death rates of patients did not differ significantly depending on their comorbidities, p> 0.05 and their clinical features. p>0.05, while the ages of the dead and non-dead were similar. p>0.05, respectively.
Conclusion : All patients in the sample had cardiovascular problems and more often heart failure, acute coronary syndrome, syncope and angina and a high mortality rate. Frequent monitoring of these patients, reassessment with regular imaging and clinical laboratory tests and aggressive treatment of risk factors are considered beneficial.
