Κατεύθυνση Αναπνευστική Ανεπάρκεια-Μηχανικός Αερισμός
Library of the School of Health Sciences

2021-06-03

2021

Marousis Konstantinos

Ιωάννης Βασιλειάδης, Αναπληρωτής Καθηγητής, Ιατρική σχολή, ΕΚΠΑ
Νικολέττα Ροβίνα, Επίκουρη Καθηγήτρια, Ιατρική σχολή, ΕΚΠΑ
Αντωνία Κουτσούκου, Καθηγήτρια, Ιατρική σχολή, ΕΚΠΑ

Νεότερα δεδομένα στα εξωσωματικά συστήματα υποστήριξης ηπατικής λειτουργίας. Συστηματική Ανασκόπηση

Greek

Latest data on extracorporeal liver support. A Systematic Review

Background. Liver is an important organ in the human body which is capable of regulating homeostasis, protein synthesis and detoxification of blood. It’s failure most of the times can be fatal, that’s why methods of extracorporeal liver assist (artificial and bioartificial) have been introduced since the start of the century.
Objective. To show possible prolongation of survival along with other benefits in patients that were cured with extracorporeal liver assist devices in contrary with standard of care treatment.
Methods. 18 randomized controlled trials from medical databases (PubMed, Medline, Cochrane Library, Google scholar, Embase) through the start of 1999 until 12/2018 have been used to extract the data. Patients that did not have liver impairment were excluded from the study.
Results-conclusion. The use of extracorporeal liver assist devices did not end in prolongation of survival in the selected patients. Although, the devices are safe to use and have particularly good results in detoxifying the plasma. More studies with better and thorough planning need to be conducted to eradicate bias and determine the clinical profits of these devices. At last it is important to find new ways to replace protein synthesis in patients with liver failure.

Health Sciences

Failure, Acute liver, Artificial liver, Acute on chronic liver failure

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https://pergamos.lib.uoa.gr/uoa/dl/object/2946162